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- W2945057743 endingPage "498" @default.
- W2945057743 startingPage "488" @default.
- W2945057743 abstract "Catechin hydrate is a phytopharmaceutical with promising anticancer effects but poor bioavailability. This study aimed to elaborate catechin loaded chitosan-tethered liposomes (chitosomes) to enhance catechin oral bioavailability. Nanocarriers were optimized via ethanol injection method followed by physicochemical, ex vivo and biological appraisal in male Wistar albino rats. Results demonstrated that chitosomes possessed excellent nanosize of 137 nm, monodispersity (PDI < 0.2) and high Zeta potential of +36.8 mV. Additionally, chitosomes showed significant improvement in digestive stability against bile salt with enhanced ex-vivo intestinal permeation. Pharmacokinetic studies revealed the significant potential of chitosomes to enhance catechin bioavailability (AUC, Cmax) and sustain its effect (Tmax). In conclusion, elaborated chitosomes are promising nanoplatforms to enhance catechin oral efficacy with lower dose, side effects, administration frequency and higher patient compliance." @default.
- W2945057743 created "2019-05-29" @default.
- W2945057743 creator A5017406842 @default.
- W2945057743 creator A5054821696 @default.
- W2945057743 creator A5059444024 @default.
- W2945057743 date "2019-06-01" @default.
- W2945057743 modified "2023-10-16" @default.
- W2945057743 title "Improved oral bioavailability of the anticancer drug catechin using chitosomes: Design, in-vitro appraisal and in-vivo studies" @default.
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- W2945057743 doi "https://doi.org/10.1016/j.ijpharm.2019.05.034" @default.