FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945075428> ?p ?o ?g. }

• W2945075428 endingPage "1075" @default.
• W2945075428 startingPage "1069" @default.
• W2945075428 abstract "During inflammation, elevated total (unbound plus protein-bound) clozapine plasma concentrations have been observed. Elevated alpha-1-acid glycoprotein concentrations during inflammation are suggested to cause increased plasma clozapine-alpha-1-acid glycoprotein binding, resulting in elevated total clozapine plasma concentrations without significant changes in unbound concentrations. Here, we investigated the association between alpha-1-acid glycoprotein plasma concentrations and clozapine unbound fraction. First, 25 and 60 µL of alpha-1-acid glycoprotein solution (20 mg/mL) were added to plasma samples (n = 3) of clozapine users (spiking experiment). Second, the association between alpha-1-acid glycoprotein plasma concentration and clozapine unbound fraction was assessed in patient samples (patient study). Samples were determined by liquid chromatography-tandem mass spectrometry. Data were analyzed with a paired t test (spiking experiment) and an unpaired t test (patient study). The spiking experiment showed significantly lower mean unbound fractions following 25- and 60-µL alpha-1-acid glycoprotein spikes (relative reductions of 28.3%, p = 0.032 and 43.4%, p = 0.048). In the patient study, total clozapine plasma concentrations were 10% higher in elevated (n = 6) compared with normal alpha-1-acid glycoprotein (n = 20) samples [525 µg/L vs. 479 µg/L, mean difference = 47 µg/L (95% confidence interval −217 to 310), p = 0.72]. Elevated alpha-1-acid glycoprotein samples had a 26% lower mean unbound fraction compared with normal samples [1.22% vs. 1.65%, mean difference = −0.43% (95% confidence interval −0.816 to −0.0443), p = 0.03]. Both the spiking experiment and patient study showed a significant association between elevated alpha-1-acid glycoprotein plasma concentrations and a lower clozapine unbound fraction. Future studies should include clinical data to examine whether this association is clinically relevant, suggesting any clozapine dose adjustments." @default.
• W2945075428 created "2019-05-29" @default.
• W2945075428 creator A5003891807 @default.
• W2945075428 creator A5011988813 @default.
• W2945075428 creator A5024588131 @default.
• W2945075428 creator A5027493575 @default.
• W2945075428 creator A5036347462 @default.
• W2945075428 creator A5036441294 @default.
• W2945075428 creator A5047607215 @default.
• W2945075428 creator A5059747918 @default.
• W2945075428 creator A5089766476 @default.
• W2945075428 date "2019-05-21" @default.
• W2945075428 modified "2023-10-06" @default.
• W2945075428 title "Unbound Fraction of Clozapine Significantly Decreases with Elevated Plasma Concentrations of the Inflammatory Acute-Phase Protein Alpha-1-Acid Glycoprotein" @default.
• W2945075428 cites W1229245056 @default.
• W2945075428 cites W1628656799 @default.
• W2945075428 cites W1970017068 @default.
• W2945075428 cites W1994095158 @default.
• W2945075428 cites W2001377918 @default.
• W2945075428 cites W2009832071 @default.
• W2945075428 cites W2013829288 @default.
• W2945075428 cites W2027374322 @default.
• W2945075428 cites W2035088108 @default.
• W2945075428 cites W2039293582 @default.
• W2945075428 cites W2043711370 @default.
• W2945075428 cites W2045184768 @default.
• W2945075428 cites W2052999592 @default.
• W2945075428 cites W2058181488 @default.
• W2945075428 cites W2071282695 @default.
• W2945075428 cites W2072121627 @default.
• W2945075428 cites W2092754854 @default.
• W2945075428 cites W2133441328 @default.
• W2945075428 cites W2330296650 @default.
• W2945075428 cites W2753966476 @default.
• W2945075428 cites W4317675664 @default.
• W2945075428 cites W656665617 @default.
• W2945075428 doi "https://doi.org/10.1007/s40262-019-00744-6" @default.
• W2945075428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6614135" @default.
• W2945075428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31111332" @default.
• W2945075428 hasPublicationYear "2019" @default.
• W2945075428 type Work @default.
• W2945075428 sameAs 2945075428 @default.
• W2945075428 citedByCount "6" @default.
• W2945075428 countsByYear W29450754282020 @default.
• W2945075428 countsByYear W29450754282021 @default.
• W2945075428 countsByYear W29450754282022 @default.
• W2945075428 countsByYear W29450754282023 @default.
• W2945075428 crossrefType "journal-article" @default.
• W2945075428 hasAuthorship W2945075428A5003891807 @default.
• W2945075428 hasAuthorship W2945075428A5011988813 @default.
• W2945075428 hasAuthorship W2945075428A5024588131 @default.
• W2945075428 hasAuthorship W2945075428A5027493575 @default.
• W2945075428 hasAuthorship W2945075428A5036347462 @default.
• W2945075428 hasAuthorship W2945075428A5036441294 @default.
• W2945075428 hasAuthorship W2945075428A5047607215 @default.
• W2945075428 hasAuthorship W2945075428A5059747918 @default.
• W2945075428 hasAuthorship W2945075428A5089766476 @default.
• W2945075428 hasBestOaLocation W29450754281 @default.
• W2945075428 hasConcept C108625454 @default.
• W2945075428 hasConcept C118552586 @default.
• W2945075428 hasConcept C126322002 @default.
• W2945075428 hasConcept C133936738 @default.
• W2945075428 hasConcept C134018914 @default.
• W2945075428 hasConcept C141071460 @default.
• W2945075428 hasConcept C146543888 @default.
• W2945075428 hasConcept C185592680 @default.
• W2945075428 hasConcept C2775944032 @default.
• W2945075428 hasConcept C2776412080 @default.
• W2945075428 hasConcept C2778707650 @default.
• W2945075428 hasConcept C2780864610 @default.
• W2945075428 hasConcept C30787643 @default.
• W2945075428 hasConcept C43617362 @default.
• W2945075428 hasConcept C44249647 @default.
• W2945075428 hasConcept C49453240 @default.
• W2945075428 hasConcept C501593827 @default.
• W2945075428 hasConcept C55493867 @default.
• W2945075428 hasConcept C64943373 @default.
• W2945075428 hasConcept C71924100 @default.
• W2945075428 hasConcept C98274493 @default.
• W2945075428 hasConceptScore W2945075428C108625454 @default.
• W2945075428 hasConceptScore W2945075428C118552586 @default.
• W2945075428 hasConceptScore W2945075428C126322002 @default.
• W2945075428 hasConceptScore W2945075428C133936738 @default.
• W2945075428 hasConceptScore W2945075428C134018914 @default.
• W2945075428 hasConceptScore W2945075428C141071460 @default.
• W2945075428 hasConceptScore W2945075428C146543888 @default.
• W2945075428 hasConceptScore W2945075428C185592680 @default.
• W2945075428 hasConceptScore W2945075428C2775944032 @default.
• W2945075428 hasConceptScore W2945075428C2776412080 @default.
• W2945075428 hasConceptScore W2945075428C2778707650 @default.
• W2945075428 hasConceptScore W2945075428C2780864610 @default.
• W2945075428 hasConceptScore W2945075428C30787643 @default.
• W2945075428 hasConceptScore W2945075428C43617362 @default.
• W2945075428 hasConceptScore W2945075428C44249647 @default.
• W2945075428 hasConceptScore W2945075428C49453240 @default.
• W2945075428 hasConceptScore W2945075428C501593827 @default.
• W2945075428 hasConceptScore W2945075428C55493867 @default.
• W2945075428 hasConceptScore W2945075428C64943373 @default.

• next