Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945120762> ?p ?o ?g. }
- W2945120762 endingPage "131" @default.
- W2945120762 startingPage "131" @default.
- W2945120762 abstract "Candida albicans is a commensal that inhabits the skin and mucous membranes of humans. Because of the increasing immunocompromised population and the limited classes of antifungal drugs available, C. albicans has emerged as an important opportunistic pathogen with high mortality rates. During infection and therapy, C. albicans frequently encounters immune cells and antifungal drugs, many of which exert their antimicrobial activity by inducing the production of reactive oxygen species (ROS). Therefore, antioxidative capacity is important for the survival and pathogenesis of C. albicans. In this study, we characterized the roles of the zinc finger transcription factor Sfp1 in the oxidative stress response against C. albicans. A sfp1-deleted mutant was more resistant to oxidants and macrophage killing than wild-type C. albicans and processed an active oxidative stress response with the phosphorylation of the mitogen-activated protein kinase (MAPK) Hog1 and high CAP1 expression. Moreover, the sfp1-deleted mutant exhibited high expression levels of antioxidant genes in response to oxidative stress, resulting in a higher total antioxidant capacity, glutathione content, and glutathione peroxidase and superoxide dismutase enzyme activity than the wild-type C. albicans. Finally, the sfp1-deleted mutant was resistant to macrophage killing and ROS-generating antifungal drugs. Together, our findings provide a new understanding of the complex regulatory machinery in the C. albicans oxidative stress response." @default.
- W2945120762 created "2019-05-29" @default.
- W2945120762 creator A5000109074 @default.
- W2945120762 creator A5011319279 @default.
- W2945120762 creator A5038771060 @default.
- W2945120762 creator A5047636038 @default.
- W2945120762 creator A5064450452 @default.
- W2945120762 date "2019-05-14" @default.
- W2945120762 modified "2023-10-13" @default.
- W2945120762 title "The Transcription Factor Sfp1 Regulates the Oxidative Stress Response in Candida albicans" @default.
- W2945120762 cites W1768247331 @default.
- W2945120762 cites W1971974933 @default.
- W2945120762 cites W1979114598 @default.
- W2945120762 cites W1983822172 @default.
- W2945120762 cites W1988100928 @default.
- W2945120762 cites W1989534897 @default.
- W2945120762 cites W1992900987 @default.
- W2945120762 cites W1994976851 @default.
- W2945120762 cites W1998436990 @default.
- W2945120762 cites W2005056606 @default.
- W2945120762 cites W2006135083 @default.
- W2945120762 cites W2014741756 @default.
- W2945120762 cites W2017679946 @default.
- W2945120762 cites W2030948786 @default.
- W2945120762 cites W2037267801 @default.
- W2945120762 cites W2037593369 @default.
- W2945120762 cites W2041190439 @default.
- W2945120762 cites W2049237396 @default.
- W2945120762 cites W2066650452 @default.
- W2945120762 cites W2069424496 @default.
- W2945120762 cites W2072268979 @default.
- W2945120762 cites W2083795747 @default.
- W2945120762 cites W2095802468 @default.
- W2945120762 cites W2096974237 @default.
- W2945120762 cites W2104880204 @default.
- W2945120762 cites W2107277218 @default.
- W2945120762 cites W2108174422 @default.
- W2945120762 cites W2109962249 @default.
- W2945120762 cites W2114911706 @default.
- W2945120762 cites W2116783422 @default.
- W2945120762 cites W2117216625 @default.
- W2945120762 cites W2118645676 @default.
- W2945120762 cites W2123114163 @default.
- W2945120762 cites W2125278887 @default.
- W2945120762 cites W2127851875 @default.
- W2945120762 cites W2131817226 @default.
- W2945120762 cites W2134035883 @default.
- W2945120762 cites W2134909835 @default.
- W2945120762 cites W2135989597 @default.
- W2945120762 cites W2137188274 @default.
- W2945120762 cites W2137428110 @default.
- W2945120762 cites W2137797941 @default.
- W2945120762 cites W2140398671 @default.
- W2945120762 cites W2143620551 @default.
- W2945120762 cites W2146807721 @default.
- W2945120762 cites W2154156375 @default.
- W2945120762 cites W2157490841 @default.
- W2945120762 cites W2160998060 @default.
- W2945120762 cites W2161243595 @default.
- W2945120762 cites W2162169873 @default.
- W2945120762 cites W2164315014 @default.
- W2945120762 cites W2167502710 @default.
- W2945120762 cites W2170040727 @default.
- W2945120762 cites W2192080449 @default.
- W2945120762 cites W2213522766 @default.
- W2945120762 cites W2229240186 @default.
- W2945120762 cites W2317317737 @default.
- W2945120762 cites W2499863882 @default.
- W2945120762 cites W2520157743 @default.
- W2945120762 cites W2529796234 @default.
- W2945120762 cites W2621136091 @default.
- W2945120762 cites W2750959598 @default.
- W2945120762 cites W2785998129 @default.
- W2945120762 cites W2923014056 @default.
- W2945120762 cites W292480129 @default.
- W2945120762 cites W4211260506 @default.
- W2945120762 cites W4237666549 @default.
- W2945120762 cites W4245957869 @default.
- W2945120762 cites W4385616449 @default.
- W2945120762 cites W578092097 @default.
- W2945120762 cites W635225177 @default.
- W2945120762 doi "https://doi.org/10.3390/microorganisms7050131" @default.
- W2945120762 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6560436" @default.
- W2945120762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31091716" @default.
- W2945120762 hasPublicationYear "2019" @default.
- W2945120762 type Work @default.
- W2945120762 sameAs 2945120762 @default.
- W2945120762 citedByCount "11" @default.
- W2945120762 countsByYear W29451207622019 @default.
- W2945120762 countsByYear W29451207622020 @default.
- W2945120762 countsByYear W29451207622021 @default.
- W2945120762 countsByYear W29451207622022 @default.
- W2945120762 countsByYear W29451207622023 @default.
- W2945120762 crossrefType "journal-article" @default.
- W2945120762 hasAuthorship W2945120762A5000109074 @default.
- W2945120762 hasAuthorship W2945120762A5011319279 @default.
- W2945120762 hasAuthorship W2945120762A5038771060 @default.
- W2945120762 hasAuthorship W2945120762A5047636038 @default.