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• W2945121430 endingPage "e1008169" @default.
• W2945121430 startingPage "e1008169" @default.
• W2945121430 abstract "The Pol32 protein is one of the universal subunits of DNA polymerase δ (Pol δ), which is responsible for genome replication in eukaryotic cells. Although the role of Pol32 in DNA repair has been well-characterized, its exact function in genome replication remains obscure as studies in single cell systems have not established an essential role for Pol32 in the process. Here we characterize Pol32 in the context of Drosophila melanogaster development. In the rapidly dividing embryonic cells, loss of Pol32 halts genome replication as it specifically disrupts Pol δ localization to the nucleus. This function of Pol32 in facilitating the nuclear import of Pol δ would be similar to that of accessory subunits of DNA polymerases from mammalian Herpes viruses. In post-embryonic cells, loss of Pol32 reveals mitotic fragile sites in the Drosophila genome, a defect more consistent with Pol32's role as a polymerase processivity factor. Interestingly, these fragile sites do not favor repetitive sequences in heterochromatin, with the rDNA locus being a striking exception. Our study uncovers a possibly universal function for DNA polymerase ancillary factors and establishes a powerful system for the study of chromosomal fragile sites in a non-mammalian organism." @default.
• W2945121430 created "2019-05-29" @default.
• W2945121430 creator A5028869361 @default.
• W2945121430 creator A5035539119 @default.
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• W2945121430 creator A5083613320 @default.
• W2945121430 creator A5090416710 @default.
• W2945121430 date "2019-05-17" @default.
• W2945121430 modified "2023-09-27" @default.
• W2945121430 title "The processivity factor Pol32 mediates nuclear localization of DNA polymerase delta and prevents chromosomal fragile site formation in Drosophila development" @default.
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• W2945121430 doi "https://doi.org/10.1371/journal.pgen.1008169" @default.
• W2945121430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6542543" @default.
• W2945121430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31100062" @default.
• W2945121430 hasPublicationYear "2019" @default.
• W2945121430 type Work @default.
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