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• W2945125923 abstract "Tumour markers in pleural fluid and their diagnostic value are subject to debate. Although there are several studies on this topic, standardized cut-off values do not exist. In this study we investigated the potential of a ratio of carcinoembryonic antigen (CEA) in pleural fluid and serum, serving as an individual marker for pleural cancer manifestation.A total of 201 consecutive patients with unclear pleural effusion were included in the study; 98 were diagnosed with malignant pleural effusion and 103 had an effusion due to other, benign reasons. CEA levels in pleural fluid and serum were measured.By using receiver operating characteristics analysis, at the cut-off of 1.0, the CEA ratio showed a specificity of 92% and sensitivity of 85%, with a positive predictive value of 91% and a negative predictive value of 87%. These results are higher than in previous investigations on different pleural tumour markers and their combination.The CEA ratio is a useful tool in predicting pleural carcinosis. Elevated results in cytology-negative patients should lead to further investigations, such as repeated cytological examination or thoracoscopy." @default.
• W2945125923 created "2019-05-29" @default.
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• W2945125923 date "2019-01-01" @default.
• W2945125923 modified "2023-10-03" @default.
• W2945125923 title "Ratio of carcinoembryonic antigen in pleural fluid and serum for the diagnosis of malignant pleural effusion" @default.
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• W2945125923 doi "https://doi.org/10.1177/1758835919850341" @default.
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