FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945127782> ?p ?o ?g. }

• W2945127782 endingPage "2401" @default.
• W2945127782 startingPage "2383" @default.
• W2945127782 abstract "The quantitative faecal immunochemical test for haemoglobin (FIT) has been revealed to be highly accurate for colorectal cancer (CRC) detection not only in a screening setting, but also in the assessment of patients presenting lower bowel symptoms. Therefore, the National Institute for Health and Care Excellence has recommended the adoption of FIT in primary care to guide referral for suspected CRC in low-risk symptomatic patients using a 10 µg Hb/g faeces threshold. Nevertheless, it is unknown whether FIT´s accuracy remains stable throughout the broad spectrum of possible symptoms.To perform a systematic review and meta-analysis to assess FIT accuracy for CRC detection in different clinical settings.A systematic literature search was performed using MEDLINE and EMBASE databases from inception to May 2018 to conduct a meta-analysis of prospective studies including symptomatic patients that evaluated the diagnostic accuracy of quantitative FIT for CRC detection. Studies were classified on the basis of brand, threshold of faecal haemoglobin concentration for a positive test result, percentage of reported symptoms (solely symptomatic, mixed cohorts) and CRC prevalence (< 2.5%, ≥ 2.5%) to limit heterogeneity and perform subgroup analysis to assess the influence of clinical spectrum on FIT´s accuracy to detect CRC.Fifteen cohorts including 13073 patients (CRC prevalence 0.4% to 16.8%) were identified. Pooled estimates of sensitivity for studies using OC-Sensor at 10 µg Hb/g faeces threshold (n = 10400) was 89.6% [95% confidence interval (CI): 82.7% to 94.0%). However, pooled estimates of sensitivity for studies formed solely by symptomatic patients (n = 4035) and mixed cohorts (n = 6365) were 94.1% (95%CI: 90.0% to 96.6%) and 85.5% (95%CI: 76.5% to 91.4%) respectively (P < 0.01), while there were no statistically significant differences between pooled sensitivity of studies with CRC prevalence < 2.5% (84.9%, 95%CI: 73.4% to 92.0%) and ≥ 2.5% (91.7%, 95%CI: 83.3% to 96.1%) (P = 0.25). At the same threshold, OC-Sensor® sensitivity to rule out any significant colonic lesion was 78.6% (95%CI: 75.6% to 81.4%). We found substantial heterogeneity especially when assessing specificity.The results of this meta-analysis confirm that, regardless of CRC prevalence, quantitative FIT is highly sensitive for CRC detection. However, FIT ability to rule out CRC is higher in studies solely including symptomatic patients." @default.
• W2945127782 created "2019-05-29" @default.
• W2945127782 creator A5018692814 @default.
• W2945127782 creator A5060930528 @default.
• W2945127782 creator A5076502627 @default.
• W2945127782 date "2019-05-21" @default.
• W2945127782 modified "2023-09-25" @default.
• W2945127782 title "High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis" @default.
• W2945127782 cites W1532021455 @default.
• W2945127782 cites W1879347689 @default.
• W2945127782 cites W1923436140 @default.
• W2945127782 cites W1946409667 @default.
• W2945127782 cites W1966279516 @default.
• W2945127782 cites W1990118688 @default.
• W2945127782 cites W1990748933 @default.
• W2945127782 cites W1994352279 @default.
• W2945127782 cites W2025833782 @default.
• W2945127782 cites W2026438625 @default.
• W2945127782 cites W2046316215 @default.
• W2945127782 cites W2065765482 @default.
• W2945127782 cites W2068382972 @default.
• W2945127782 cites W2078848825 @default.
• W2945127782 cites W2083417681 @default.
• W2945127782 cites W2102073243 @default.
• W2945127782 cites W2106261190 @default.
• W2945127782 cites W2107328434 @default.
• W2945127782 cites W2107638293 @default.
• W2945127782 cites W2116710480 @default.
• W2945127782 cites W2126727011 @default.
• W2945127782 cites W2127229704 @default.
• W2945127782 cites W2132515539 @default.
• W2945127782 cites W2134719667 @default.
• W2945127782 cites W2142866564 @default.
• W2945127782 cites W2144420447 @default.
• W2945127782 cites W2147549359 @default.
• W2945127782 cites W2151047141 @default.
• W2945127782 cites W2156098321 @default.
• W2945127782 cites W2162467118 @default.
• W2945127782 cites W2163689545 @default.
• W2945127782 cites W2169160087 @default.
• W2945127782 cites W2317633151 @default.
• W2945127782 cites W2400237760 @default.
• W2945127782 cites W2411275938 @default.
• W2945127782 cites W2417673889 @default.
• W2945127782 cites W246286872 @default.
• W2945127782 cites W2520528185 @default.
• W2945127782 cites W2550226825 @default.
• W2945127782 cites W2557843658 @default.
• W2945127782 cites W2586554704 @default.
• W2945127782 cites W2596444943 @default.
• W2945127782 cites W2765474761 @default.
• W2945127782 cites W2770669093 @default.
• W2945127782 cites W2787171349 @default.
• W2945127782 cites W2793856038 @default.
• W2945127782 cites W2898436077 @default.
• W2945127782 cites W2903759724 @default.
• W2945127782 cites W4294215472 @default.
• W2945127782 doi "https://doi.org/10.3748/wjg.v25.i19.2383" @default.
• W2945127782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6529892" @default.
• W2945127782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31148909" @default.
• W2945127782 hasPublicationYear "2019" @default.
• W2945127782 type Work @default.
• W2945127782 sameAs 2945127782 @default.
• W2945127782 citedByCount "35" @default.
• W2945127782 countsByYear W29451277822020 @default.
• W2945127782 countsByYear W29451277822021 @default.
• W2945127782 countsByYear W29451277822022 @default.
• W2945127782 countsByYear W29451277822023 @default.
• W2945127782 crossrefType "journal-article" @default.
• W2945127782 hasAuthorship W2945127782A5018692814 @default.
• W2945127782 hasAuthorship W2945127782A5060930528 @default.
• W2945127782 hasAuthorship W2945127782A5076502627 @default.
• W2945127782 hasBestOaLocation W29451277821 @default.
• W2945127782 hasConcept C121608353 @default.
• W2945127782 hasConcept C126322002 @default.
• W2945127782 hasConcept C17744445 @default.
• W2945127782 hasConcept C189708586 @default.
• W2945127782 hasConcept C199539241 @default.
• W2945127782 hasConcept C2776135927 @default.
• W2945127782 hasConcept C2779473830 @default.
• W2945127782 hasConcept C2780439572 @default.
• W2945127782 hasConcept C44249647 @default.
• W2945127782 hasConcept C512399662 @default.
• W2945127782 hasConcept C526805850 @default.
• W2945127782 hasConcept C71924100 @default.
• W2945127782 hasConcept C82789193 @default.
• W2945127782 hasConcept C95190672 @default.
• W2945127782 hasConceptScore W2945127782C121608353 @default.
• W2945127782 hasConceptScore W2945127782C126322002 @default.
• W2945127782 hasConceptScore W2945127782C17744445 @default.
• W2945127782 hasConceptScore W2945127782C189708586 @default.
• W2945127782 hasConceptScore W2945127782C199539241 @default.
• W2945127782 hasConceptScore W2945127782C2776135927 @default.
• W2945127782 hasConceptScore W2945127782C2779473830 @default.
• W2945127782 hasConceptScore W2945127782C2780439572 @default.
• W2945127782 hasConceptScore W2945127782C44249647 @default.
• W2945127782 hasConceptScore W2945127782C512399662 @default.
• W2945127782 hasConceptScore W2945127782C526805850 @default.

• next