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- W2945133385 abstract "3129 With the advent of effective therapies for testicular cancer and improved long-term survival, the clinical implications of late effects of therapy are becoming increasingly important. We quantified the risk of second cancers among 13,764 one-year survivors of testicular cancer, including 1,713 20-year survivors, reported to 9 population-based cancer registries that comprise the SEER Program (1973 –2000). Excluding contralateral testis, 620 second cancers were observed (O) compared with 481 expected (E) (O/E ratio = 1.3; 95% CI = 1.2 –1.4), resulting in an excess absolute risk of 9.6 cancers per 10,000 men per year. Significant excesses were observed for acute nonlymphocytic leukemia (ANLL) (O/E = 4.0) and cancers of the rectum (O/E = 1.7), pancreas (O/E = 2.5), urinary bladder (O/E = 1.6), kidney (O/E = 1.7), and thyroid (O/E = 2.0). Risks for all second cancers other than testis were 1.3, 1.2, 1.2, and 1.4, respectively, at 1-4 years, 5-9 years, 10-19 years, and 20 or more years after testis cancer diagnosis ( P trend = 0.42). Among patients whose initial course of treatment included radiotherapy, corresponding risks were 1.2, 1.3, 1.3, and 1.6 ( P trend = 0.36); risks among other patients were 1.3, 0.9, 1.0, and 1.3, respectively. Elevated risks of solid tumors (O/E = 1.4; 95% CI = 1.1 –1.8) among 20-year survivors included bladder cancer (O/E = 3.0, P" @default.
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- W2945133385 date "2004-04-01" @default.
- W2945133385 modified "2023-09-23" @default.
- W2945133385 title "Second malignant neoplasms among long-term survivors of testicular cancer." @default.
- W2945133385 hasPublicationYear "2004" @default.
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