FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945149682> ?p ?o ?g. }

• W2945149682 endingPage "793" @default.
• W2945149682 startingPage "783" @default.
• W2945149682 abstract "There are conflicting results regarding how APOE genotype, the strongest genetic risk factor for Alzheimer’s disease (AD), influences spatial and longitudinal amyloid-β (Aβ) deposition and its impact on the selection of biomarker cut-points. In our study, we sought to determine the impact of APOE g enotype on cross-sectional and longitudinal florbetapir positron emission tomography (PET) amyloid measures and its impact in classification of patients and interpretation of clinical cohort results. We included 1,019 and 1,072 Alzheimer’s Disease Neuroimaging Initiative participants with cerebrospinal fluid Aβ1 - 42 and florbetapir PET values, respectively. 623 of these subjects had a second florbetapir PET scans two years after the baseline visit. We evaluated the effect of APOE genotype on Aβ distribution pattern, pathological biomarker cut-points, cross-sectional clinical associations with Aβ load, and longitudinal Aβ deposition rate measured using florbetapir PET scans. 1) APOE ɛ4 genotype influences brain amyloid deposition pattern; 2) APOE ɛ4 genotype does not modify Aβ biomarker cut-points estimated using unsupervised mixture modeling methods if white matter and brainstem references are used (but not when cerebellum is used as a reference); 3) findings of large differences in Aβ biomarker value differences based on APOE genotype are due to increased probability of having AD neuropathology and are most significant in mild cognitive impairment subjects; and 4) APOE genotype and age (but not gender) were associated with increased Aβ deposition rate. APOE ɛ4 carrier status affects rate and location of brain Aβ deposition but does not affect choice of biomarker cut-points if adequate references are selected for florbetapir PET processing." @default.
• W2945149682 created "2019-05-29" @default.
• W2945149682 creator A5002543602 @default.
• W2945149682 creator A5019478049 @default.
• W2945149682 creator A5021394368 @default.
• W2945149682 creator A5023136222 @default.
• W2945149682 creator A5032267453 @default.
• W2945149682 creator A5034999945 @default.
• W2945149682 creator A5035352293 @default.
• W2945149682 creator A5043086041 @default.
• W2945149682 creator A5047842737 @default.
• W2945149682 creator A5086700948 @default.
• W2945149682 date "2019-06-04" @default.
• W2945149682 modified "2023-10-18" @default.
• W2945149682 title "APOE Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points" @default.
• W2945149682 cites W1538814448 @default.
• W2945149682 cites W1825683130 @default.
• W2945149682 cites W1936590007 @default.
• W2945149682 cites W1967823816 @default.
• W2945149682 cites W1988370080 @default.
• W2945149682 cites W1990143520 @default.
• W2945149682 cites W1993571512 @default.
• W2945149682 cites W2003428745 @default.
• W2945149682 cites W2004136146 @default.
• W2945149682 cites W2007044705 @default.
• W2945149682 cites W2008301592 @default.
• W2945149682 cites W2010695389 @default.
• W2945149682 cites W2011832962 @default.
• W2945149682 cites W2018715207 @default.
• W2945149682 cites W2022371215 @default.
• W2945149682 cites W2024269867 @default.
• W2945149682 cites W2025983435 @default.
• W2945149682 cites W2042397283 @default.
• W2945149682 cites W2047125512 @default.
• W2945149682 cites W2050255138 @default.
• W2945149682 cites W2051489981 @default.
• W2945149682 cites W2059963640 @default.
• W2945149682 cites W2072639724 @default.
• W2945149682 cites W2074109912 @default.
• W2945149682 cites W2075193321 @default.
• W2945149682 cites W2075444764 @default.
• W2945149682 cites W2106729009 @default.
• W2945149682 cites W2112499304 @default.
• W2945149682 cites W2112882050 @default.
• W2945149682 cites W2113518834 @default.
• W2945149682 cites W2122328291 @default.
• W2945149682 cites W2128228199 @default.
• W2945149682 cites W2129771097 @default.
• W2945149682 cites W2133649359 @default.
• W2945149682 cites W2134711807 @default.
• W2945149682 cites W2148161188 @default.
• W2945149682 cites W2150481150 @default.
• W2945149682 cites W2160597466 @default.
• W2945149682 cites W2168873176 @default.
• W2945149682 cites W2257069458 @default.
• W2945149682 cites W2364709612 @default.
• W2945149682 doi "https://doi.org/10.3233/jad-181282" @default.
• W2945149682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8634544" @default.
• W2945149682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31127775" @default.
• W2945149682 hasPublicationYear "2019" @default.
• W2945149682 type Work @default.
• W2945149682 sameAs 2945149682 @default.
• W2945149682 citedByCount "15" @default.
• W2945149682 countsByYear W29451496822019 @default.
• W2945149682 countsByYear W29451496822020 @default.
• W2945149682 countsByYear W29451496822021 @default.
• W2945149682 countsByYear W29451496822022 @default.
• W2945149682 countsByYear W29451496822023 @default.
• W2945149682 crossrefType "journal-article" @default.
• W2945149682 hasAuthorship W2945149682A5002543602 @default.
• W2945149682 hasAuthorship W2945149682A5019478049 @default.
• W2945149682 hasAuthorship W2945149682A5021394368 @default.
• W2945149682 hasAuthorship W2945149682A5023136222 @default.
• W2945149682 hasAuthorship W2945149682A5032267453 @default.
• W2945149682 hasAuthorship W2945149682A5034999945 @default.
• W2945149682 hasAuthorship W2945149682A5035352293 @default.
• W2945149682 hasAuthorship W2945149682A5043086041 @default.
• W2945149682 hasAuthorship W2945149682A5047842737 @default.
• W2945149682 hasAuthorship W2945149682A5086700948 @default.
• W2945149682 hasBestOaLocation W29451496822 @default.
• W2945149682 hasConcept C126322002 @default.
• W2945149682 hasConcept C126838900 @default.
• W2945149682 hasConcept C142724271 @default.
• W2945149682 hasConcept C143409427 @default.
• W2945149682 hasConcept C143998085 @default.
• W2945149682 hasConcept C15744967 @default.
• W2945149682 hasConcept C169760540 @default.
• W2945149682 hasConcept C2775842073 @default.
• W2945149682 hasConcept C2777633098 @default.
• W2945149682 hasConcept C2779134260 @default.
• W2945149682 hasConcept C2779651940 @default.
• W2945149682 hasConcept C2780130745 @default.
• W2945149682 hasConcept C2781073650 @default.
• W2945149682 hasConcept C2781197716 @default.
• W2945149682 hasConcept C45664433 @default.
• W2945149682 hasConcept C502032728 @default.
• W2945149682 hasConcept C54355233 @default.
• W2945149682 hasConcept C57089818 @default.

• next