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- W2945154138 abstract "HSV entry is a multistep process that requires the actions of four glycoproteins, gD, gH/gL, and gB. Our current model predicts that gD must interact with both its receptor and gH/gL to promote viral entry. Although we know a great deal about how gD binds its receptors, until now we have been unable to demonstrate a direct interaction between gD and gH/gL. Here, we used a highly sensitive surface plasmon resonance technique to clearly demonstrate that gD and gH/gL interact. Furthermore, using multiple MAbs with defined epitopes, we have delineated a domain on gD that is independent of that used for receptor binding and which likely represents the gH/gL interaction domain. Targeting this interaction to prevent fusion may enhance both therapeutic and vaccine strategies." @default.
- W2945154138 created "2019-05-29" @default.
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- W2945154138 date "2019-08-01" @default.
- W2945154138 modified "2023-10-01" @default.
- W2945154138 title "Surface Plasmon Resonance Reveals Direct Binding of Herpes Simplex Virus Glycoproteins gH/gL to gD and Locates a gH/gL Binding Site on gD" @default.
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- W2945154138 doi "https://doi.org/10.1128/jvi.00289-19" @default.
- W2945154138 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6639271" @default.
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- W2945154138 hasPublicationYear "2019" @default.
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