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- W2945156762 endingPage "935" @default.
- W2945156762 startingPage "903" @default.
- W2945156762 abstract "As the process that silences gene expression ensues during development, the stage is set for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene profiles. PRC2 catalyzes a specific histone posttranslational modification (hPTM) that fosters chromatin compaction. PRC2 also facilitates the inheritance of this hPTM through its self-contained write and read activities, key to preserving cellular identity during cell division. As these changes in gene expression occur without changes in DNA sequence and are inherited, the process is epigenetic in scope. Mutants of mammalian PRC2 or of its histone substrate contribute to the cancer process and other diseases, and research into these aberrant pathways is yielding viable candidates for therapeutic targeting. The effectiveness of PRC2 hinges on its being recruited to the proper chromatin sites; however, resolving the determinants to this process in the mammalian case was not straightforward and thus piqued the interest of many in the field. Here, we chronicle the latest advances toward exposing mammalian PRC2 and its high maintenance." @default.
- W2945156762 created "2019-05-29" @default.
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- W2945156762 creator A5043210560 @default.
- W2945156762 creator A5054326054 @default.
- W2945156762 creator A5087448455 @default.
- W2945156762 date "2019-05-23" @default.
- W2945156762 modified "2023-10-14" @default.
- W2945156762 title "PRC2 is high maintenance" @default.
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