FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945167249> ?p ?o ?g. }

• W2945167249 endingPage "119" @default.
• W2945167249 startingPage "108" @default.
• W2945167249 abstract "This study describes the development of a novel and sensitive UPLC-MS/MS method for simultaneous determination of diethyl phthalate (DEP) and its major metabolite, monoethyl phthalate (MEP), in rat plasma, urine, and 11 different tissues collected from a toxicokinetic study. Analytes were separated using 0.1% (v/v) aqueous formic acid and acetonitrile containing 0.1% (v/v) formic acid as a mobile phase by gradient elution at a flow rate of 0.25 mL/min with a KINETEX core-shell C18 column (50 × 2.1 mm, 1.7 μm). Quantitation was performed on a triple quadrupole mass spectrometer employing electrospray ionization technique operated in multiple reaction monitoring. The assay achieved lower limit of quantification for 0.04 ng/mL of DEP and 0.1 ng/mL of MEP in plasma, urine, and all tissues. The disposition of DEP was characterized by short half-life (1.30-1.34 h) and a high clearance (11.76 ± 0.08 L/h/kg). It was rapidly metabolized to MEP. Its levels consistently exceeded DEP levels. The tissue distribution of DEP and MEP of liver, kidney, gastro-intestinal tract, spleen, testis, lung, brain, muscle, thymus, heart, and adipose was determined at 24 h after drug administration. For DEP, the tissue to plasma partition coefficient was the highest in the kidney (16.72), followed by that in the liver (10.04), spleen (1.35), and adipose (1.18). For MEP, the tissue to plasma partition coefficient was the highest in the liver (2.18). It was less than unity for all other tissues. The developed analytical method satisfied the criteria of international guidance. It could be successfully applied to toxicokinetic studies of DEP after oral and intravenous administration of DEP to rats. In addition, findings of this study may be useful to evaluate exposure and toxic potential of DEP and its metabolite in risk assessment." @default.
• W2945167249 created "2019-05-29" @default.
• W2945167249 creator A5014972082 @default.
• W2945167249 creator A5063915727 @default.
• W2945167249 creator A5067194755 @default.
• W2945167249 creator A5071118371 @default.
• W2945167249 date "2019-09-01" @default.
• W2945167249 modified "2023-10-18" @default.
• W2945167249 title "Simultaneous determination of diethyl phthalate and its major metabolite, monoethyl phthalate, in rat plasma, urine, and various tissues collected from a toxicokinetic study by ultrahigh performance liquid chromatography-tandem mass spectrometry" @default.
• W2945167249 cites W1968872157 @default.
• W2945167249 cites W1973167599 @default.
• W2945167249 cites W1989429411 @default.
• W2945167249 cites W1989564369 @default.
• W2945167249 cites W1990112228 @default.
• W2945167249 cites W2002746497 @default.
• W2945167249 cites W2003649314 @default.
• W2945167249 cites W2007134977 @default.
• W2945167249 cites W2019913219 @default.
• W2945167249 cites W2023635770 @default.
• W2945167249 cites W2024031182 @default.
• W2945167249 cites W2024047546 @default.
• W2945167249 cites W2039887848 @default.
• W2945167249 cites W2039960524 @default.
• W2945167249 cites W2044329979 @default.
• W2945167249 cites W2066166372 @default.
• W2945167249 cites W2071616652 @default.
• W2945167249 cites W2073090912 @default.
• W2945167249 cites W2081473365 @default.
• W2945167249 cites W2083531531 @default.
• W2945167249 cites W2086937888 @default.
• W2945167249 cites W2087175878 @default.
• W2945167249 cites W2092966130 @default.
• W2945167249 cites W2163417923 @default.
• W2945167249 cites W2167118827 @default.
• W2945167249 cites W4213257437 @default.
• W2945167249 cites W49021375 @default.
• W2945167249 doi "https://doi.org/10.1016/j.jpba.2019.05.027" @default.
• W2945167249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31125947" @default.
• W2945167249 hasPublicationYear "2019" @default.
• W2945167249 type Work @default.
• W2945167249 sameAs 2945167249 @default.
• W2945167249 citedByCount "9" @default.
• W2945167249 countsByYear W29451672492020 @default.
• W2945167249 countsByYear W29451672492021 @default.
• W2945167249 countsByYear W29451672492022 @default.
• W2945167249 countsByYear W29451672492023 @default.
• W2945167249 crossrefType "journal-article" @default.
• W2945167249 hasAuthorship W2945167249A5014972082 @default.
• W2945167249 hasAuthorship W2945167249A5063915727 @default.
• W2945167249 hasAuthorship W2945167249A5067194755 @default.
• W2945167249 hasAuthorship W2945167249A5071118371 @default.
• W2945167249 hasConcept C162356407 @default.
• W2945167249 hasConcept C172493649 @default.
• W2945167249 hasConcept C178790620 @default.
• W2945167249 hasConcept C185592680 @default.
• W2945167249 hasConcept C195289149 @default.
• W2945167249 hasConcept C2777379063 @default.
• W2945167249 hasConcept C2777477808 @default.
• W2945167249 hasConcept C2780026642 @default.
• W2945167249 hasConcept C2781005124 @default.
• W2945167249 hasConcept C31827203 @default.
• W2945167249 hasConcept C43617362 @default.
• W2945167249 hasConcept C55493867 @default.
• W2945167249 hasConcept C62231903 @default.
• W2945167249 hasConcept C71043704 @default.
• W2945167249 hasConceptScore W2945167249C162356407 @default.
• W2945167249 hasConceptScore W2945167249C172493649 @default.
• W2945167249 hasConceptScore W2945167249C178790620 @default.
• W2945167249 hasConceptScore W2945167249C185592680 @default.
• W2945167249 hasConceptScore W2945167249C195289149 @default.
• W2945167249 hasConceptScore W2945167249C2777379063 @default.
• W2945167249 hasConceptScore W2945167249C2777477808 @default.
• W2945167249 hasConceptScore W2945167249C2780026642 @default.
• W2945167249 hasConceptScore W2945167249C2781005124 @default.
• W2945167249 hasConceptScore W2945167249C31827203 @default.
• W2945167249 hasConceptScore W2945167249C43617362 @default.
• W2945167249 hasConceptScore W2945167249C55493867 @default.
• W2945167249 hasConceptScore W2945167249C62231903 @default.
• W2945167249 hasConceptScore W2945167249C71043704 @default.
• W2945167249 hasLocation W29451672491 @default.
• W2945167249 hasLocation W29451672492 @default.
• W2945167249 hasOpenAccess W2945167249 @default.
• W2945167249 hasPrimaryLocation W29451672491 @default.
• W2945167249 hasRelatedWork W2027171267 @default.
• W2945167249 hasRelatedWork W2050356041 @default.
• W2945167249 hasRelatedWork W2057478567 @default.
• W2945167249 hasRelatedWork W2068718322 @default.
• W2945167249 hasRelatedWork W2161713195 @default.
• W2945167249 hasRelatedWork W2229858648 @default.
• W2945167249 hasRelatedWork W2360345623 @default.
• W2945167249 hasRelatedWork W2392271453 @default.
• W2945167249 hasRelatedWork W2804295861 @default.
• W2945167249 hasRelatedWork W3194462057 @default.
• W2945167249 hasVolume "173" @default.
• W2945167249 isParatext "false" @default.
• W2945167249 isRetracted "false" @default.
• W2945167249 magId "2945167249" @default.
• W2945167249 workType "article" @default.