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- W2945168319 abstract "Amyotrophic lateral sclerosis (ALS) is the most common motor neuron degenerative disease in adults and has also been proven to be a type of conformational disease associated with protein misfolding and dysfunction. To date, more than 150 distinct genes have been found to be associated with ALS, among which Superoxide Dismutase 1 (SOD1) is the first and the most extensively studied gene. It has been well-established that SOD1 mutants-mediated toxicity is caused by a gain-of-function rather than the loss of the detoxifying activity of SOD1. Compared with the clear autosomal dominant inheritance of SOD1 mutants in ALS, the potential toxic mechanisms of SOD1 mutants in motor neurons remain incompletely understood. A large body of evidence has shown that SOD1 mutants may adopt a complex profile of conformations and interact with a wide range of client proteins. Here, in this review, we summarize the fundamental conformational properties and the gained interaction partners of the soluble forms of the SOD1 mutants which have been published in the past decades. Our goal is to find clues to the possible internal links between structural and functional anomalies of SOD1 mutants, as well as the relationships between their exposed epitopes and interaction partners, in order to help reveal and determine potential diagnostic and therapeutic targets." @default.
- W2945168319 created "2019-05-29" @default.
- W2945168319 creator A5035043158 @default.
- W2945168319 creator A5060646510 @default.
- W2945168319 date "2019-05-21" @default.
- W2945168319 modified "2023-10-16" @default.
- W2945168319 title "Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants" @default.
- W2945168319 cites W1191729939 @default.
- W2945168319 cites W1488155304 @default.
- W2945168319 cites W1488561241 @default.
- W2945168319 cites W1523693806 @default.
- W2945168319 cites W1583282648 @default.
- W2945168319 cites W170104472 @default.
- W2945168319 cites W179329376 @default.
- W2945168319 cites W184862045 @default.
- W2945168319 cites W1916595758 @default.
- W2945168319 cites W1967050619 @default.
- W2945168319 cites W1969157127 @default.
- W2945168319 cites W1974856379 @default.
- W2945168319 cites W1975462016 @default.
- W2945168319 cites W1975549226 @default.
- W2945168319 cites W1977711433 @default.
- W2945168319 cites W1981020468 @default.
- W2945168319 cites W1981625315 @default.
- W2945168319 cites W1984589592 @default.
- W2945168319 cites W1985023569 @default.
- W2945168319 cites W1985124617 @default.
- W2945168319 cites W1986513151 @default.
- W2945168319 cites W1986659198 @default.
- W2945168319 cites W1988239088 @default.
- W2945168319 cites W1990619980 @default.
- W2945168319 cites W1994823455 @default.
- W2945168319 cites W1995686474 @default.
- W2945168319 cites W1997000467 @default.
- W2945168319 cites W2000291566 @default.
- W2945168319 cites W2000604907 @default.
- W2945168319 cites W2002368498 @default.
- W2945168319 cites W2002502450 @default.
- W2945168319 cites W2004978936 @default.
- W2945168319 cites W2008092626 @default.
- W2945168319 cites W2008452978 @default.
- W2945168319 cites W2012969896 @default.
- W2945168319 cites W2013135033 @default.
- W2945168319 cites W2014011193 @default.
- W2945168319 cites W2014497390 @default.
- W2945168319 cites W2015116101 @default.
- W2945168319 cites W2020930265 @default.
- W2945168319 cites W2021639930 @default.
- W2945168319 cites W2023459278 @default.
- W2945168319 cites W2024952866 @default.
- W2945168319 cites W2025629415 @default.
- W2945168319 cites W2025872915 @default.
- W2945168319 cites W2031226474 @default.
- W2945168319 cites W2031751971 @default.
- W2945168319 cites W2032162800 @default.
- W2945168319 cites W2032670789 @default.
- W2945168319 cites W2033056129 @default.
- W2945168319 cites W2034651824 @default.
- W2945168319 cites W2038941603 @default.
- W2945168319 cites W2042662902 @default.
- W2945168319 cites W2042665202 @default.
- W2945168319 cites W2043811492 @default.
- W2945168319 cites W2045479131 @default.
- W2945168319 cites W2048423613 @default.
- W2945168319 cites W2050155052 @default.
- W2945168319 cites W2050280746 @default.
- W2945168319 cites W2050373464 @default.
- W2945168319 cites W2050972526 @default.
- W2945168319 cites W2051401615 @default.
- W2945168319 cites W2054630268 @default.
- W2945168319 cites W2057097767 @default.
- W2945168319 cites W2057139034 @default.
- W2945168319 cites W2057256807 @default.
- W2945168319 cites W2057838250 @default.
- W2945168319 cites W2063043143 @default.
- W2945168319 cites W2063363475 @default.
- W2945168319 cites W2063403801 @default.
- W2945168319 cites W2064904709 @default.
- W2945168319 cites W2067472104 @default.
- W2945168319 cites W2069221404 @default.
- W2945168319 cites W2070720564 @default.
- W2945168319 cites W2071242789 @default.
- W2945168319 cites W2072978915 @default.
- W2945168319 cites W2081324081 @default.
- W2945168319 cites W2089159887 @default.
- W2945168319 cites W2090078115 @default.
- W2945168319 cites W2093730959 @default.
- W2945168319 cites W2096386031 @default.
- W2945168319 cites W2096880567 @default.
- W2945168319 cites W2101571804 @default.
- W2945168319 cites W2104099868 @default.
- W2945168319 cites W2106297709 @default.
- W2945168319 cites W2106819616 @default.
- W2945168319 cites W2106988699 @default.
- W2945168319 cites W2107672209 @default.
- W2945168319 cites W2107768418 @default.
- W2945168319 cites W2109679459 @default.
- W2945168319 cites W2114452685 @default.
- W2945168319 cites W2117481030 @default.
- W2945168319 cites W2118343035 @default.