Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945170743> ?p ?o ?g. }
- W2945170743 endingPage "1586" @default.
- W2945170743 startingPage "1574" @default.
- W2945170743 abstract "Abstract Background Free light chains (FLC) have been proposed as diagnostic biomarkers in the cerebrospinal fluid (CSF) of patients with inflammatory central nervous system (CNS) diseases. However, which method to use for determining an intrathecal FLC synthesis has not yet been clarified. The objective of this study was to compare the diagnostic performance of CSF FLC concentration, FLC quotient (Q FLC ), FLC index and FLC intrathecal fraction (FLC IF ). Methods κ- and λ-FLC were measured by nephelometry under blinded conditions in CSF and serum sample pairs of patients with clinically isolated syndrome (CIS; n = 60), multiple sclerosis (MS; n = 60) and other neurological diseases (n = 60) from four different MS centers. Q FLC was calculated as the ratio of CSF/serum FLC concentration, the FLC index as Q FLC /albumin quotient and the percentage FLC IF by comparing Q FLC to a previously empirically determined, albumin quotient-dependent reference limit. Results CSF FLC concentration, Q FLC , FLC index and FLC IF of both the κ- and λ-isotype were significantly higher in patients with CIS and MS than in the control group, as well as in oligoclonal bands (OCB) positive than in OCB negative patients. Each parameter was able to identify MS/CIS patients and OCB positivity, however, diagnostic performance determined by receiver operating characteristic (ROC) analyses differed and revealed superiority of FLC index and FLC IF . Conclusions These findings support the diagnostic value of FLC measures that correct for serum FLC levels and albumin quotient, i.e. blood-CSF barrier function." @default.
- W2945170743 created "2019-05-29" @default.
- W2945170743 creator A5002105884 @default.
- W2945170743 creator A5005660483 @default.
- W2945170743 creator A5006812976 @default.
- W2945170743 creator A5012301485 @default.
- W2945170743 creator A5014894550 @default.
- W2945170743 creator A5021936961 @default.
- W2945170743 creator A5056770086 @default.
- W2945170743 creator A5056983959 @default.
- W2945170743 date "2019-05-21" @default.
- W2945170743 modified "2023-10-04" @default.
- W2945170743 title "Free light chains in the cerebrospinal fluid. Comparison of different methods to determine intrathecal synthesis" @default.
- W2945170743 cites W1595791613 @default.
- W2945170743 cites W1861434948 @default.
- W2945170743 cites W1965797688 @default.
- W2945170743 cites W1967138600 @default.
- W2945170743 cites W1971703603 @default.
- W2945170743 cites W1974367364 @default.
- W2945170743 cites W1994723621 @default.
- W2945170743 cites W2031694038 @default.
- W2945170743 cites W2037635086 @default.
- W2945170743 cites W2040876374 @default.
- W2945170743 cites W2065496524 @default.
- W2945170743 cites W2074485666 @default.
- W2945170743 cites W2080477550 @default.
- W2945170743 cites W2082706341 @default.
- W2945170743 cites W2112935184 @default.
- W2945170743 cites W2119029887 @default.
- W2945170743 cites W2124240218 @default.
- W2945170743 cites W2129719133 @default.
- W2945170743 cites W2129741039 @default.
- W2945170743 cites W2135440918 @default.
- W2945170743 cites W2145715226 @default.
- W2945170743 cites W2164371036 @default.
- W2945170743 cites W2173853912 @default.
- W2945170743 cites W2198953147 @default.
- W2945170743 cites W2318354323 @default.
- W2945170743 cites W2345786512 @default.
- W2945170743 cites W2766799416 @default.
- W2945170743 cites W2792124252 @default.
- W2945170743 cites W2850662870 @default.
- W2945170743 cites W2883187593 @default.
- W2945170743 cites W2887513179 @default.
- W2945170743 cites W2893662218 @default.
- W2945170743 cites W2904339575 @default.
- W2945170743 cites W2916040650 @default.
- W2945170743 doi "https://doi.org/10.1515/cclm-2018-1300" @default.
- W2945170743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31112501" @default.
- W2945170743 hasPublicationYear "2019" @default.
- W2945170743 type Work @default.
- W2945170743 sameAs 2945170743 @default.
- W2945170743 citedByCount "24" @default.
- W2945170743 countsByYear W29451707432020 @default.
- W2945170743 countsByYear W29451707432021 @default.
- W2945170743 countsByYear W29451707432022 @default.
- W2945170743 countsByYear W29451707432023 @default.
- W2945170743 crossrefType "journal-article" @default.
- W2945170743 hasAuthorship W2945170743A5002105884 @default.
- W2945170743 hasAuthorship W2945170743A5005660483 @default.
- W2945170743 hasAuthorship W2945170743A5006812976 @default.
- W2945170743 hasAuthorship W2945170743A5012301485 @default.
- W2945170743 hasAuthorship W2945170743A5014894550 @default.
- W2945170743 hasAuthorship W2945170743A5021936961 @default.
- W2945170743 hasAuthorship W2945170743A5056770086 @default.
- W2945170743 hasAuthorship W2945170743A5056983959 @default.
- W2945170743 hasConcept C114614502 @default.
- W2945170743 hasConcept C126322002 @default.
- W2945170743 hasConcept C141071460 @default.
- W2945170743 hasConcept C157820659 @default.
- W2945170743 hasConcept C159654299 @default.
- W2945170743 hasConcept C164585084 @default.
- W2945170743 hasConcept C185592680 @default.
- W2945170743 hasConcept C199422724 @default.
- W2945170743 hasConcept C203014093 @default.
- W2945170743 hasConcept C2776125364 @default.
- W2945170743 hasConcept C2777991845 @default.
- W2945170743 hasConcept C2779651940 @default.
- W2945170743 hasConcept C2780640218 @default.
- W2945170743 hasConcept C33923547 @default.
- W2945170743 hasConcept C542903549 @default.
- W2945170743 hasConcept C71924100 @default.
- W2945170743 hasConceptScore W2945170743C114614502 @default.
- W2945170743 hasConceptScore W2945170743C126322002 @default.
- W2945170743 hasConceptScore W2945170743C141071460 @default.
- W2945170743 hasConceptScore W2945170743C157820659 @default.
- W2945170743 hasConceptScore W2945170743C159654299 @default.
- W2945170743 hasConceptScore W2945170743C164585084 @default.
- W2945170743 hasConceptScore W2945170743C185592680 @default.
- W2945170743 hasConceptScore W2945170743C199422724 @default.
- W2945170743 hasConceptScore W2945170743C203014093 @default.
- W2945170743 hasConceptScore W2945170743C2776125364 @default.
- W2945170743 hasConceptScore W2945170743C2777991845 @default.
- W2945170743 hasConceptScore W2945170743C2779651940 @default.
- W2945170743 hasConceptScore W2945170743C2780640218 @default.
- W2945170743 hasConceptScore W2945170743C33923547 @default.
- W2945170743 hasConceptScore W2945170743C542903549 @default.
- W2945170743 hasConceptScore W2945170743C71924100 @default.