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- W2945173807 endingPage "1873" @default.
- W2945173807 startingPage "1865" @default.
- W2945173807 abstract "Molecules that bind to tubulin and disrupt tubulin dynamics are known as microtubule targeting agents. Treatment with a microtubule targeting agent leads to cell cycle arrest followed by apoptosis. Tubulin inhibitors have been highly effective in the clinical treatment of a variety of tumors and are being investigated for treatment of several other diseases. Currently, all FDA approved microtubule inhibitors bind to β-tubulin. Given the overall success of tubulin-binding agents in anticancer chemotherapy, α-tubulin is an attractive and unexplored target. Herein, we will discuss pironetin, the only compound known to bind α-tubulin, with particular focus on the known biological properties, the total syntheses, exploration of its structure-activity relationship, and future directions." @default.
- W2945173807 created "2019-05-29" @default.
- W2945173807 creator A5022178148 @default.
- W2945173807 creator A5046229101 @default.
- W2945173807 date "2019-08-01" @default.
- W2945173807 modified "2023-10-12" @default.
- W2945173807 title "Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics" @default.
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- W2945173807 doi "https://doi.org/10.1016/j.bmcl.2019.05.042" @default.
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