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- W2945177467 endingPage "7417" @default.
- W2945177467 startingPage "7402" @default.
- W2945177467 abstract "Abstract The CRISPR system is widely used in genome editing for biomedical research. Here, using either dual paired Cas9D10A nickases or paired Cas9 nuclease we characterize unintended larger deletions at on-target sites that frequently evade common genotyping practices. We found that unintended larger deletions are prevalent at multiple distinct loci on different chromosomes, in cultured cells and mouse embryos alike. We observed a high frequency of microhomologies at larger deletion breakpoint junctions, suggesting the involvement of microhomology-mediated end joining in their generation. In populations of edited cells, the distribution of larger deletion sizes is dependent on proximity to sgRNAs and cannot be predicted by microhomology sequences alone." @default.
- W2945177467 created "2019-05-29" @default.
- W2945177467 creator A5007511672 @default.
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- W2945177467 creator A5042070999 @default.
- W2945177467 creator A5051439814 @default.
- W2945177467 creator A5051903816 @default.
- W2945177467 date "2019-05-25" @default.
- W2945177467 modified "2023-10-18" @default.
- W2945177467 title "Microhomologies are prevalent at Cas9-induced larger deletions" @default.
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