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- W2945177527 abstract "Given by the i.v. route to healthy volunteers, indobufen has an half-life of 7-9 h. After oral administration of tablets, the drug is completely absorbed. Excretion occurs through the kidney and the drug is present in the urine as glucoronide and in unchanged form. The maximum inhibitory effect on collagen-induced platelet aggregation was observed 1 to 4 h after i.v. and p.o. administration but activity at 8 h was more marked after p.o. administration in accordance with the higher plasma levels found at that time. During repeated administration at the dose of 100 mg b.i.d. for 7 days, no important changes in kinetic parameters and activity of indobufen was observed. Indobufen is rapidly absorbed also when given by the i.m. route, giving at 30 min peak levels comparable to those observed after oral administration. These data suggest that indobufen is active by the i.V., p.o. and i.m. routes, that its effect on platelets, unlike ASA, is reversible, and that its kinetics is linear." @default.
- W2945177527 created "2019-05-29" @default.
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- W2945177527 date "1979-01-01" @default.
- W2945177527 modified "2023-09-26" @default.
- W2945177527 title "Human Pharmacology Studies in Volunteers with Indobufen (K 3920), Inhibitor of Platelet Aggregation" @default.
- W2945177527 doi "https://doi.org/10.1055/s-0039-1684449" @default.
- W2945177527 hasPublicationYear "1979" @default.
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