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- W2945183023 abstract "BACKGROUND: Magnesium sulphate is an important adjuvant drug in anaesthesia. In combination with rocuronium, it can enhance neuromuscular blockade. Deep neuromuscular blockade is increasingly used in laparoscopic surgical procedures, with promising patient outcomes. OBJECTIVES: The aim of this study was to determine the role of magnesium sulphate on the duration of deep and intense neuromuscular blockade with rocuronium. METHODS: Randomised, double-blind clinical study. Sixty patients scheduled to undergo elective otorhinolaryngological surgery under general anaesthesia were pre-treated with an intravenous infusion of either 100 ml saline (saline group), or 60 mg/kg magnesium sulphate (sulphate group), before induction of anaesthesia. Randomisation was performed using the GraphPad Prism QuickCalcs program. A rocuronium bolus (0.6 mg/kg) was administered after loss of consciousness. Neuromuscular function was assessed using acceleration of the thumb adductor, measured with the train-of-four (TOF) Watch SX® monitor. The Stockholm revision protocol was adopted. Neuromuscular outcome data included onset time and period of no response (no response to TOF). RESULTS: Median (IQR) durations of deep neuromuscular blockade were: 20.31 (12.03 – 35.39) min and 18.27 (11.21 – 26.28) min in the magnesium sulphate and saline groups, respectively (p = 0.1809). Median (IQR) durations of intense neuromuscular blockade were 21.68 (0.00 – 32.15) min and 0.00 (0.00 – 16.23) min (p = 0.0011) in the magnesium sulphate and saline groups, respectively. CONCLUSION: Magnesium sulphate increased the duration of intense neuromuscular blockade and the period of no response. There was no difference in patients in terms of deep neuromuscular blockade. In patients treated with magnesium sulphate, neuromuscular monitoring and adequate reversal are essential" @default.
- W2945183023 created "2019-05-29" @default.
- W2945183023 creator A5051810266 @default.
- W2945183023 date "2018-01-01" @default.
- W2945183023 modified "2023-09-27" @default.
- W2945183023 title "Efeito do pré-tratamento com sulfato de magnésio sobre a duração do bloqueio neuromuscular intenso e profundo com rocurônio: estudo clínico aleatório e duplamente encoberto" @default.
- W2945183023 doi "https://doi.org/10.22409/ppgcm.2018.m.03133321773" @default.
- W2945183023 hasPublicationYear "2018" @default.
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