FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945185414> ?p ?o ?g. }

• W2945185414 endingPage "1674" @default.
• W2945185414 startingPage "1660" @default.
• W2945185414 abstract "Cervical dystonia is a neurological disorder characterized by sustained, involuntary movements of the head and neck. Most cases of cervical dystonia are idiopathic, with no obvious cause, yet some cases are acquired, secondary to focal brain lesions. These latter cases are valuable as they establish a causal link between neuroanatomy and resultant symptoms, lending insight into the brain regions causing cervical dystonia and possible treatment targets. However, lesions causing cervical dystonia can occur in multiple different brain locations, leaving localization unclear. Here, we use a technique termed ‘lesion network mapping’, which uses connectome data from a large cohort of healthy subjects (resting state functional MRI, n = 1000) to test whether lesion locations causing cervical dystonia map to a common brain network. We then test whether this network, derived from brain lesions, is abnormal in patients with idiopathic cervical dystonia (n = 39) versus matched controls (n = 37). A systematic literature search identified 25 cases of lesion-induced cervical dystonia. Lesion locations were heterogeneous, with lesions scattered throughout the cerebellum, brainstem, and basal ganglia. However, these heterogeneous lesion locations were all part of a single functionally connected brain network. Positive connectivity to the cerebellum and negative connectivity to the somatosensory cortex were specific markers for cervical dystonia compared to lesions causing other neurological symptoms. Connectivity with these two regions defined a single brain network that encompassed the heterogeneous lesion locations causing cervical dystonia. These cerebellar and somatosensory regions also showed abnormal connectivity in patients with idiopathic cervical dystonia. Finally, the most effective deep brain stimulation sites for treating dystonia were connected to these same cerebellar and somatosensory regions identified using lesion network mapping. These results lend insight into the causal neuroanatomical substrate of cervical dystonia, demonstrate convergence across idiopathic and acquired dystonia, and identify a network target for dystonia treatment." @default.
• W2945185414 created "2019-05-29" @default.
• W2945185414 creator A5009239817 @default.
• W2945185414 creator A5014203878 @default.
• W2945185414 creator A5026007088 @default.
• W2945185414 creator A5032531676 @default.
• W2945185414 creator A5041908513 @default.
• W2945185414 creator A5046826096 @default.
• W2945185414 creator A5060960336 @default.
• W2945185414 creator A5066680883 @default.
• W2945185414 creator A5068526895 @default.
• W2945185414 creator A5069893379 @default.
• W2945185414 creator A5071626950 @default.
• W2945185414 creator A5072542068 @default.
• W2945185414 creator A5080605797 @default.
• W2945185414 creator A5091678814 @default.
• W2945185414 date "2019-05-28" @default.
• W2945185414 modified "2023-10-17" @default.
• W2945185414 title "Network localization of cervical dystonia based on causal brain lesions" @default.
• W2945185414 cites W1458229720 @default.
• W2945185414 cites W1760829075 @default.
• W2945185414 cites W177563509 @default.
• W2945185414 cites W1778028538 @default.
• W2945185414 cites W180528046 @default.
• W2945185414 cites W1842943691 @default.
• W2945185414 cites W1968263341 @default.
• W2945185414 cites W1969441482 @default.
• W2945185414 cites W1976127998 @default.
• W2945185414 cites W1977175164 @default.
• W2945185414 cites W1980213732 @default.
• W2945185414 cites W1986320574 @default.
• W2945185414 cites W1986781153 @default.
• W2945185414 cites W1991573881 @default.
• W2945185414 cites W1992906232 @default.
• W2945185414 cites W2002952398 @default.
• W2945185414 cites W2005409822 @default.
• W2945185414 cites W2005877468 @default.
• W2945185414 cites W2007729962 @default.
• W2945185414 cites W2025663766 @default.
• W2945185414 cites W2027284728 @default.
• W2945185414 cites W2028800900 @default.
• W2945185414 cites W2030471788 @default.
• W2945185414 cites W2034742337 @default.
• W2945185414 cites W2035628906 @default.
• W2945185414 cites W2037654143 @default.
• W2945185414 cites W2041331984 @default.
• W2945185414 cites W2041813662 @default.
• W2945185414 cites W2046641753 @default.
• W2945185414 cites W2050082690 @default.
• W2945185414 cites W2050359248 @default.
• W2945185414 cites W2051239559 @default.
• W2945185414 cites W2053486159 @default.
• W2945185414 cites W2055160110 @default.
• W2945185414 cites W2056455197 @default.
• W2945185414 cites W2059886556 @default.
• W2945185414 cites W2061014549 @default.
• W2945185414 cites W2065540111 @default.
• W2945185414 cites W2067456724 @default.
• W2945185414 cites W2076261766 @default.
• W2945185414 cites W2082641523 @default.
• W2945185414 cites W2090073632 @default.
• W2945185414 cites W2091046222 @default.
• W2945185414 cites W2107362968 @default.
• W2945185414 cites W2113916316 @default.
• W2945185414 cites W2121690122 @default.
• W2945185414 cites W2124088053 @default.
• W2945185414 cites W2124283721 @default.
• W2945185414 cites W2126693856 @default.
• W2945185414 cites W2130010412 @default.
• W2945185414 cites W2131134103 @default.
• W2945185414 cites W2134305330 @default.
• W2945185414 cites W2134820284 @default.
• W2945185414 cites W2135922545 @default.
• W2945185414 cites W2136139557 @default.
• W2945185414 cites W2143661428 @default.
• W2945185414 cites W2143947644 @default.
• W2945185414 cites W2147980755 @default.
• W2945185414 cites W2154435473 @default.
• W2945185414 cites W2156612553 @default.
• W2945185414 cites W2157602863 @default.
• W2945185414 cites W2159014717 @default.
• W2945185414 cites W2163999192 @default.
• W2945185414 cites W2166562076 @default.
• W2945185414 cites W21769058 @default.
• W2945185414 cites W2195234723 @default.
• W2945185414 cites W2307176359 @default.
• W2945185414 cites W2355701054 @default.
• W2945185414 cites W2415424257 @default.
• W2945185414 cites W2426018132 @default.
• W2945185414 cites W2471509212 @default.
• W2945185414 cites W2480011246 @default.
• W2945185414 cites W2520584845 @default.
• W2945185414 cites W2547120907 @default.
• W2945185414 cites W2555801507 @default.
• W2945185414 cites W2557111525 @default.
• W2945185414 cites W2565603412 @default.
• W2945185414 cites W2579735770 @default.
• W2945185414 cites W2616426212 @default.

• next