Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945188072> ?p ?o ?g. }
- W2945188072 endingPage "2613" @default.
- W2945188072 startingPage "2606" @default.
- W2945188072 abstract "Abacavir administration is associated with drug-induced hypersensitivity reactions in HIV+ individuals expressing the HLA-B*57:01 allele. However, the immunological effects of abacavir administration in an HLA-B57 mismatched transplantation setting have not been studied. We hypothesized that abacavir exposure could induce de novo HLA-B57-specific allorecognition. HIV-specific CD8 T cell clones were generated from HIV+ individuals, using single cell sorting based on HIV peptide/HLA tetramer staining. The T cell clones were assayed for alloreactivity against a panel of single HLA-expressing cell lines, in the presence or absence of abacavir. Cytokine assay, CD137 upregulation, and cytotoxicity were used as readout. Abacavir exposure can induce de novo HLA-B57 allorecognition by HIV-specific T cells. A HIV Gag RK9/HLA-A3-specific T cell did exhibit interferon-γ production, CD137 upregulation, and cytolytic effector function against allogeneic HLA-B57, but only in the presence of abacavir. Allorecognition was specific to the virus specificity, HLA restriction, and T cell receptor TRBV use of the T cell. We provide proof-of-principle evidence that administration of a drug could induce specific allorecognition of mismatched HLA molecules in the transplant setting. We suggest that HIV-seropositive recipients of an HLA-B57 mismatched graft should not receive abacavir until further studies are completed." @default.
- W2945188072 created "2019-05-29" @default.
- W2945188072 creator A5001517294 @default.
- W2945188072 creator A5005231347 @default.
- W2945188072 creator A5006444238 @default.
- W2945188072 creator A5021544227 @default.
- W2945188072 creator A5053321929 @default.
- W2945188072 creator A5063205034 @default.
- W2945188072 creator A5066623545 @default.
- W2945188072 creator A5067048300 @default.
- W2945188072 creator A5074323255 @default.
- W2945188072 creator A5083545834 @default.
- W2945188072 date "2019-09-01" @default.
- W2945188072 modified "2023-10-18" @default.
- W2945188072 title "Drug-induced alloreactivity: A new paradigm for allorecognition" @default.
- W2945188072 cites W1590531419 @default.
- W2945188072 cites W1861758047 @default.
- W2945188072 cites W1912675534 @default.
- W2945188072 cites W1978518799 @default.
- W2945188072 cites W1981084653 @default.
- W2945188072 cites W1985359245 @default.
- W2945188072 cites W1990865051 @default.
- W2945188072 cites W2019855029 @default.
- W2945188072 cites W2020251267 @default.
- W2945188072 cites W2045249816 @default.
- W2945188072 cites W2049747948 @default.
- W2945188072 cites W2071044636 @default.
- W2945188072 cites W2076125315 @default.
- W2945188072 cites W2080615724 @default.
- W2945188072 cites W2117577070 @default.
- W2945188072 cites W2134373673 @default.
- W2945188072 cites W2137146513 @default.
- W2945188072 cites W2140055542 @default.
- W2945188072 cites W2146652028 @default.
- W2945188072 cites W2153697534 @default.
- W2945188072 cites W2167312349 @default.
- W2945188072 cites W2602176321 @default.
- W2945188072 cites W71091497 @default.
- W2945188072 doi "https://doi.org/10.1111/ajt.15470" @default.
- W2945188072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31125485" @default.
- W2945188072 hasPublicationYear "2019" @default.
- W2945188072 type Work @default.
- W2945188072 sameAs 2945188072 @default.
- W2945188072 citedByCount "2" @default.
- W2945188072 countsByYear W29451880722020 @default.
- W2945188072 crossrefType "journal-article" @default.
- W2945188072 hasAuthorship W2945188072A5001517294 @default.
- W2945188072 hasAuthorship W2945188072A5005231347 @default.
- W2945188072 hasAuthorship W2945188072A5006444238 @default.
- W2945188072 hasAuthorship W2945188072A5021544227 @default.
- W2945188072 hasAuthorship W2945188072A5053321929 @default.
- W2945188072 hasAuthorship W2945188072A5063205034 @default.
- W2945188072 hasAuthorship W2945188072A5066623545 @default.
- W2945188072 hasAuthorship W2945188072A5067048300 @default.
- W2945188072 hasAuthorship W2945188072A5074323255 @default.
- W2945188072 hasAuthorship W2945188072A5083545834 @default.
- W2945188072 hasBestOaLocation W29451880721 @default.
- W2945188072 hasConcept C126322002 @default.
- W2945188072 hasConcept C142462285 @default.
- W2945188072 hasConcept C147483822 @default.
- W2945188072 hasConcept C147969180 @default.
- W2945188072 hasConcept C167672396 @default.
- W2945188072 hasConcept C188280979 @default.
- W2945188072 hasConcept C200315206 @default.
- W2945188072 hasConcept C203014093 @default.
- W2945188072 hasConcept C2522874641 @default.
- W2945188072 hasConcept C2776090121 @default.
- W2945188072 hasConcept C2779465607 @default.
- W2945188072 hasConcept C2911091166 @default.
- W2945188072 hasConcept C2993143319 @default.
- W2945188072 hasConcept C71924100 @default.
- W2945188072 hasConcept C86803240 @default.
- W2945188072 hasConcept C8891405 @default.
- W2945188072 hasConceptScore W2945188072C126322002 @default.
- W2945188072 hasConceptScore W2945188072C142462285 @default.
- W2945188072 hasConceptScore W2945188072C147483822 @default.
- W2945188072 hasConceptScore W2945188072C147969180 @default.
- W2945188072 hasConceptScore W2945188072C167672396 @default.
- W2945188072 hasConceptScore W2945188072C188280979 @default.
- W2945188072 hasConceptScore W2945188072C200315206 @default.
- W2945188072 hasConceptScore W2945188072C203014093 @default.
- W2945188072 hasConceptScore W2945188072C2522874641 @default.
- W2945188072 hasConceptScore W2945188072C2776090121 @default.
- W2945188072 hasConceptScore W2945188072C2779465607 @default.
- W2945188072 hasConceptScore W2945188072C2911091166 @default.
- W2945188072 hasConceptScore W2945188072C2993143319 @default.
- W2945188072 hasConceptScore W2945188072C71924100 @default.
- W2945188072 hasConceptScore W2945188072C86803240 @default.
- W2945188072 hasConceptScore W2945188072C8891405 @default.
- W2945188072 hasIssue "9" @default.
- W2945188072 hasLocation W29451880721 @default.
- W2945188072 hasLocation W29451880722 @default.
- W2945188072 hasOpenAccess W2945188072 @default.
- W2945188072 hasPrimaryLocation W29451880721 @default.
- W2945188072 hasRelatedWork W1546513461 @default.
- W2945188072 hasRelatedWork W1597102844 @default.
- W2945188072 hasRelatedWork W2023919916 @default.
- W2945188072 hasRelatedWork W2029976065 @default.