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• W2945188422 endingPage "637" @default.
• W2945188422 startingPage "624" @default.
• W2945188422 abstract "The non-steroidal anti-inflammatory drug diclofenac (DCF) threatens the health of aquatic animals and ecosystems. In the present study, different biological endpoints (mortality, development and growth, abnormalities, cardiotoxicity, neurotoxicity and antioxidant system) were used to characterize the acute and chronic effects of DCF (at concentrations ranging between 125 and 4000 μg L−1) on two amphibian species from Argentina (Trachycephalus typhonius and Physalaemus albonotatus). Results showed that the larval developmental, growth rates, and body condition of DCF-exposed individuals of both species were significantly reduced. DCF-exposed individuals also showed several morphological abnormalities, including significantly altered body axis, chondrocranium and hyobranchial skeleton, and organ and visceral abnormalities including cardiac hypoplasia, malrotated guts, asymmetrically inverted guts, and cholecystitis. DCF also had a significant effect on the swimming performance of both species: at low concentrations (125 and 250 μg L−1), swimming distance, velocity and global activity decreased, whereas, at high concentrations (1000 and 2000 μg L−1), these behavioral responses increased. Regarding cardiac function and rhythm, at DCF concentrations higher than 1000 μg L−1, the heart frequency and ventricular systole interval of both species were significantly reduced. Regarding the antioxidant system, the activity of acetylcholinesterase indicated that DCF is neurotoxic and thus related to the changes in behavioral performance. The DCF concentrations studied produced a biochemical imbalance between radical oxygen species production and antioxidant systems. The sensitivities to sublethal and chronic DCF exposure in both anuran species were similar, thus indicating the inherent complexity involved in understanding the biotoxic effects of DCF." @default.
• W2945188422 created "2019-05-29" @default.
• W2945188422 creator A5004044670 @default.
• W2945188422 creator A5010731742 @default.
• W2945188422 creator A5024713955 @default.
• W2945188422 creator A5037570816 @default.
• W2945188422 creator A5045673160 @default.
• W2945188422 creator A5060592402 @default.
• W2945188422 date "2019-09-01" @default.
• W2945188422 modified "2023-10-17" @default.
• W2945188422 title "Biotoxicity of diclofenac on two larval amphibians: Assessment of development, growth, cardiac function and rhythm, behavior and antioxidant system" @default.
• W2945188422 cites W1581414347 @default.
• W2945188422 cites W1776806509 @default.
• W2945188422 cites W1922658233 @default.
• W2945188422 cites W1949115194 @default.
• W2945188422 cites W1956947810 @default.
• W2945188422 cites W1964378056 @default.
• W2945188422 cites W1966206163 @default.
• W2945188422 cites W1967197414 @default.
• W2945188422 cites W1967304129 @default.
• W2945188422 cites W1968316487 @default.
• W2945188422 cites W1971048984 @default.
• W2945188422 cites W1977287607 @default.
• W2945188422 cites W1981795975 @default.
• W2945188422 cites W1982020741 @default.
• W2945188422 cites W1983178913 @default.
• W2945188422 cites W1986716688 @default.
• W2945188422 cites W1990148642 @default.
• W2945188422 cites W1993926520 @default.
• W2945188422 cites W1994444904 @default.
• W2945188422 cites W1998826499 @default.
• W2945188422 cites W1999074746 @default.
• W2945188422 cites W2000873209 @default.
• W2945188422 cites W2004731856 @default.
• W2945188422 cites W2006136808 @default.
• W2945188422 cites W2007692081 @default.
• W2945188422 cites W2010769021 @default.
• W2945188422 cites W2013236961 @default.
• W2945188422 cites W2023397985 @default.
• W2945188422 cites W2029760511 @default.
• W2945188422 cites W2033532463 @default.
• W2945188422 cites W2033733810 @default.
• W2945188422 cites W2035583825 @default.
• W2945188422 cites W2035689300 @default.
• W2945188422 cites W2036949163 @default.
• W2945188422 cites W2037207105 @default.
• W2945188422 cites W2037880480 @default.
• W2945188422 cites W2038185740 @default.
• W2945188422 cites W2041698712 @default.
• W2945188422 cites W2041792434 @default.
• W2945188422 cites W2043535122 @default.
• W2945188422 cites W2047209209 @default.
• W2945188422 cites W2048244792 @default.
• W2945188422 cites W2056346656 @default.
• W2945188422 cites W2057944621 @default.
• W2945188422 cites W2063666835 @default.
• W2945188422 cites W2064281959 @default.
• W2945188422 cites W2069563927 @default.
• W2945188422 cites W2071850153 @default.
• W2945188422 cites W2074631487 @default.
• W2945188422 cites W2076999198 @default.
• W2945188422 cites W2079353308 @default.
• W2945188422 cites W2080883474 @default.
• W2945188422 cites W2089482438 @default.
• W2945188422 cites W2090471098 @default.
• W2945188422 cites W2092142958 @default.
• W2945188422 cites W2093788704 @default.
• W2945188422 cites W2094694936 @default.
• W2945188422 cites W2099080801 @default.
• W2945188422 cites W2100310253 @default.
• W2945188422 cites W2101586155 @default.
• W2945188422 cites W2107648723 @default.
• W2945188422 cites W2108976411 @default.
• W2945188422 cites W2123139182 @default.
• W2945188422 cites W2125274929 @default.
• W2945188422 cites W2126277206 @default.
• W2945188422 cites W2148568928 @default.
• W2945188422 cites W2148989249 @default.
• W2945188422 cites W2152838006 @default.
• W2945188422 cites W2161857374 @default.
• W2945188422 cites W2163804259 @default.
• W2945188422 cites W2166084060 @default.
• W2945188422 cites W2313614754 @default.
• W2945188422 cites W2319552512 @default.
• W2945188422 cites W2329037349 @default.
• W2945188422 cites W2410468614 @default.
• W2945188422 cites W2519879681 @default.
• W2945188422 cites W2530781935 @default.
• W2945188422 cites W2546915340 @default.
• W2945188422 cites W255808519 @default.
• W2945188422 cites W2583836241 @default.
• W2945188422 cites W2589241447 @default.
• W2945188422 cites W2595626559 @default.
• W2945188422 cites W2601835993 @default.
• W2945188422 cites W2605544348 @default.
• W2945188422 cites W2606423235 @default.
• W2945188422 cites W2607461515 @default.
• W2945188422 cites W2613783138 @default.

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