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- W2945190068 endingPage "111118" @default.
- W2945190068 startingPage "111118" @default.
- W2945190068 abstract "Aging refers to the progressive deterioration of tissue and organ function over time. Increasing evidence points to the accumulation of highly damaged cell cycle-arrested cells with age (cellular senescence) as major reason for the development of certain aging-associated diseases. Recent studies have independently shown that aneuploidy, an abnormal chromosome set, occurs in senescent cells, and that the accumulation of cytoplasmic DNA driven by faulty chromosome segregation during mitosis aids in the establishment of senescence and its associated secretory phenotype known as SASP. Here we review the emerging link between chromosomal instability (CIN) and senescence in the context of aging, with emphasis on the cGAS-STING pathway activation and its role in the development of the SASP. Based on current evidence, we propose that age-associated CIN in mitotically active cells contributes to aging and its associated diseases, and we discuss the inhibition of CIN as a potential strategy to prevent the generation of aneuploid senescent cells and thereby to delay aging." @default.
- W2945190068 created "2019-05-29" @default.
- W2945190068 creator A5048728800 @default.
- W2945190068 creator A5076418872 @default.
- W2945190068 date "2019-09-01" @default.
- W2945190068 modified "2023-10-02" @default.
- W2945190068 title "Chromosomal instability and pro-inflammatory response in aging" @default.
- W2945190068 cites W1120256502 @default.
- W2945190068 cites W1501881225 @default.
- W2945190068 cites W1558701786 @default.
- W2945190068 cites W1567040584 @default.
- W2945190068 cites W1594574415 @default.
- W2945190068 cites W1601755300 @default.
- W2945190068 cites W1898887656 @default.
- W2945190068 cites W1929156901 @default.
- W2945190068 cites W1963660578 @default.
- W2945190068 cites W1965037168 @default.
- W2945190068 cites W1965560988 @default.
- W2945190068 cites W1966669440 @default.
- W2945190068 cites W1976635482 @default.
- W2945190068 cites W1977362098 @default.
- W2945190068 cites W1979765208 @default.
- W2945190068 cites W1980923315 @default.
- W2945190068 cites W1987531976 @default.
- W2945190068 cites W1994826332 @default.
- W2945190068 cites W2001733842 @default.
- W2945190068 cites W2003674452 @default.
- W2945190068 cites W2004196283 @default.
- W2945190068 cites W2004273407 @default.
- W2945190068 cites W2004314923 @default.
- W2945190068 cites W2006141070 @default.
- W2945190068 cites W2010417927 @default.
- W2945190068 cites W2010641214 @default.
- W2945190068 cites W2010839055 @default.
- W2945190068 cites W2011677622 @default.
- W2945190068 cites W2017046792 @default.
- W2945190068 cites W2017137665 @default.
- W2945190068 cites W2017417561 @default.
- W2945190068 cites W2017919550 @default.
- W2945190068 cites W2021488377 @default.
- W2945190068 cites W2022527641 @default.
- W2945190068 cites W2023095530 @default.
- W2945190068 cites W2024209230 @default.
- W2945190068 cites W2025224836 @default.
- W2945190068 cites W2025377342 @default.
- W2945190068 cites W2029620476 @default.
- W2945190068 cites W2038998835 @default.
- W2945190068 cites W2042140414 @default.
- W2945190068 cites W2046640968 @default.
- W2945190068 cites W2048657237 @default.
- W2945190068 cites W2050852029 @default.
- W2945190068 cites W2059370490 @default.
- W2945190068 cites W2062517636 @default.
- W2945190068 cites W2062777166 @default.
- W2945190068 cites W2063249182 @default.
- W2945190068 cites W2064154744 @default.
- W2945190068 cites W2064871936 @default.
- W2945190068 cites W2065564965 @default.
- W2945190068 cites W2066803056 @default.
- W2945190068 cites W2069519394 @default.
- W2945190068 cites W2071411183 @default.
- W2945190068 cites W2073429636 @default.
- W2945190068 cites W2074548008 @default.
- W2945190068 cites W2075688750 @default.
- W2945190068 cites W2076690763 @default.
- W2945190068 cites W2077145482 @default.
- W2945190068 cites W2077450385 @default.
- W2945190068 cites W2083147016 @default.
- W2945190068 cites W2084289371 @default.
- W2945190068 cites W2084880831 @default.
- W2945190068 cites W2087404852 @default.
- W2945190068 cites W2088566849 @default.
- W2945190068 cites W2090067193 @default.
- W2945190068 cites W2091369486 @default.
- W2945190068 cites W2094375019 @default.
- W2945190068 cites W2094746916 @default.
- W2945190068 cites W2094863064 @default.
- W2945190068 cites W2095617425 @default.
- W2945190068 cites W2096587251 @default.
- W2945190068 cites W2097049162 @default.
- W2945190068 cites W2097265055 @default.
- W2945190068 cites W2097890451 @default.
- W2945190068 cites W2098318897 @default.
- W2945190068 cites W2099610218 @default.
- W2945190068 cites W2102960342 @default.
- W2945190068 cites W2103735571 @default.
- W2945190068 cites W2103909278 @default.
- W2945190068 cites W2104222537 @default.
- W2945190068 cites W2104908670 @default.
- W2945190068 cites W2107387055 @default.
- W2945190068 cites W2109948920 @default.
- W2945190068 cites W2115104198 @default.
- W2945190068 cites W2115496959 @default.
- W2945190068 cites W2116784956 @default.
- W2945190068 cites W2117912210 @default.
- W2945190068 cites W2126525177 @default.
- W2945190068 cites W2128172647 @default.
- W2945190068 cites W2129155846 @default.