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• W2945204410 abstract "Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are efficacious for the prevention of migraine headaches. The downstream molecular mechanisms following ligand-receptor blockade by which these antibodies prevent CGRP signaling through CGRP receptors have not been demonstrated. Here we produced tool monoclonal functional antagonist antibodies against CGRP and its canonical receptor and developed a novel cellular model using fluorogen-activated protein technology that allows detection of CGRP receptor internalization by flow cytometry and, for an extended time course, visualization by confocal microscopy. Using this cell model we showed that these antagonist antibodies block both CGRP-induced cAMP signaling and CGRP receptor internalization. At least 10-fold higher concentrations of either antibody are necessary to block CGRP receptor internalization compared with cAMP accumulation in our cell model. These data reinforce our understanding of how monoclonal functional antagonist antibodies interfere with CGRP signaling." @default.
• W2945204410 created "2019-05-29" @default.
• W2945204410 creator A5004923473 @default.
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• W2945204410 date "2019-04-30" @default.
• W2945204410 modified "2023-10-18" @default.
• W2945204410 title "Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking" @default.
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• W2945204410 doi "https://doi.org/10.1186/s10194-019-0992-1" @default.
• W2945204410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6734291" @default.
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• W2945204410 hasPublicationYear "2019" @default.
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