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- W2945212255 abstract "Osteocytes are the most abundant bone cells. They are completely encased in mineralized tissue, sitting inside lacunae that are connected by a multitude of canaliculi. In recent years, the osteocyte network has been shown to fulfill endocrine functions and to communicate with a number of other organs. This review addresses emerging knowledge on the connectome of the lacunocanalicular network in different types of bone tissue. Recent advances in three-dimensional imaging technology started to reveal parameters that are well known from general theory to characterize the function of networks, such as network density, degree of nodes, or shortest path length through the network. The connectome of the lacunocanalicular network differs in some aspects between lamellar and woven bone and seems to change with age. More research is needed to relate network structure to function, such as intercellular transport or communication and its role in mechanosensation, as well as to understand the effect of diseases." @default.
- W2945212255 created "2019-05-29" @default.
- W2945212255 creator A5005495276 @default.
- W2945212255 creator A5066320586 @default.
- W2945212255 creator A5074706395 @default.
- W2945212255 date "2019-05-15" @default.
- W2945212255 modified "2023-09-26" @default.
- W2945212255 title "Towards a Connectomic Description of the Osteocyte Lacunocanalicular Network in Bone" @default.
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- W2945212255 doi "https://doi.org/10.1007/s11914-019-00515-z" @default.
- W2945212255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6647446" @default.
- W2945212255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31093871" @default.
- W2945212255 hasPublicationYear "2019" @default.
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