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• W2945225851 abstract "ABSTRACT Fibrous dysplasia (FD) is a mosaic skeletal disorder resulting in fractures, deformity, and functional impairment. Clinical evaluation has been limited by a lack of surrogate endpoints capable of quantitating disease activity. The purpose of this study was to investigate the utility of 18 F‐NaF PET/CT imaging in quantifying disease activity in patients with FD. Fifteen consecutively evaluated subjects underwent whole‐body 18 F‐NaF PET/CT scans, and FD burden was assessed by quantifying FD‐related 18 F‐NaF activity. 18 F‐NaF PET/CT parameters obtained included (i) SUV max (standardized uptake value [SUV] of the FD lesion with the highest uptake); (ii) SUV mean (average SUV of all 18 F‐NaF–positive FD lesions); (iii) total volume of all 18 F‐NaF–positive FD lesions (TV); and (iv) total FD lesion activity determined as the product of TV multiplied by SUV mean (TA = TV × SUV mean ) (TA). Skeletal outcomes, functional outcomes, and bone turnover markers were correlated with 18 F‐NaF PET/CT parameters. TV and TA of extracranial FD lesions correlated strongly with skeletal outcomes including fractures and surgeries ( p values ≤ 0.003). Subjects with impaired ambulation and scoliosis had significantly higher TV and TA values ( P < 0.05), obtained from extracranial and spinal lesions, respectively. Craniofacial surgeries correlated with TV and TA of skull FD lesions ( P < 0.001). Bone turnover markers, including alkaline phosphatase, N‐telopeptides, and osteocalcin, were strongly correlated with TV and TA ( P < 0.05) extracted from FD lesions in the entire skeleton. No associations were identified with SUV max or SUV mean . Bone pain and age did not correlate with 18 F‐NaF PET/CT parameters. FD burden evaluated by 18 F‐NaF‐PET/CT facilitates accurate assessment of FD activity, and correlates quantitatively with clinically‐relevant skeletal outcomes. © 2019 American Society for Bone and Mineral Research." @default.
• W2945225851 created "2019-05-29" @default.
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• W2945225851 date "2019-05-22" @default.
• W2945225851 modified "2023-10-17" @default.
• W2945225851 title "¹⁸F‐N<scp>a</scp>F PET/CT IMAGING IN FIBROUS DYSPLASIA OF BONE" @default.
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• W2945225851 doi "https://doi.org/10.1002/jbmr.3738" @default.
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