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- W2945233472 endingPage "700" @default.
- W2945233472 startingPage "645" @default.
- W2945233472 abstract "Streptococcus pneumoniae (Spn) and Streptococcus pyogenes (Spy) cause many invasive and noninvasive diseases responsible for high morbidity and mortality worldwide. Safe, efficacious and affordable vaccines could have a significant, positive impact on the global infectious disease burden. Since the implementation of pneumococcal vaccine in the 1980s, the incidence of Spn infection has decreased significantly. Still so, these currently used multivalent polysaccharides and conjugated pneumococcal vaccines have some limitations. For Spy, there are even no vaccines available yet. There is an urgent need of new vaccines against Spn and Spy. Encouragingly, with the hard work of many investigators worldwide, a number of new vaccines candidates are developed with promising results. Of them, many have already entered the clinical trial stage. This review will describe the current status of Spn and Spy vaccine development, with particular focus on protein-based strategy." @default.
- W2945233472 created "2019-05-29" @default.
- W2945233472 creator A5007681919 @default.
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- W2945233472 date "2019-01-01" @default.
- W2945233472 modified "2023-09-25" @default.
- W2945233472 title "Recent Advances in Pathogenic <i>Streptococcus</i> Vaccine Development" @default.
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- W2945233472 doi "https://doi.org/10.21775/cimb.032.645" @default.
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