FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945235910> ?p ?o ?g. }

• W2945235910 endingPage "1911" @default.
• W2945235910 startingPage "1911" @default.
• W2945235910 abstract "Cardiovascular disease is one of the leading causes of morbidity and mortality worldwide. Mangiferin is a natural glucosylxanthone with antioxidant and anti-inflammatory properties, which has been confirmed to protect cardiac cells from myocardial infarction and myocardial ischemia reperfusion injury (MIRI); however, the underlying mechanism is still unclear. As oxidative stress is a major pathogenesis of MIRI, an H9C2 cell injury induced by hydrogen peroxide (H2O2) was established to simulate MIRI in vitro. Herein, the protective effect of mangiferin against MIRI was evaluated and the isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics was applied to explore the underlying molecular mechanism. In this research, mangiferin markedly ameliorated the oxidative imbalance by increasing the antioxidative capacity of the H9C2 cell. Moreover, proteomics analysis revealed that mangiferin pretreatment brought twenty differently-expressed proteins back to normal, most of which were related to glucose and fatty acid metabolism. Glycolysis, citrate cycle, and fatty acid degradation pathways were highlighted by Kyoto Encyclopedia of Gene and Genomes (KEGG) analysis. Western blot validation of six cardiac metabolism-related proteins were consistent with the proteomics analysis. Taken together, mangiferin protected the cardiomyocytes from MIRI by enhancing the antioxidant capacity and increasing the activities of glycolysis, citrate cycle, and fatty acid degradation pathways." @default.
• W2945235910 created "2019-05-29" @default.
• W2945235910 creator A5012219112 @default.
• W2945235910 creator A5015195367 @default.
• W2945235910 creator A5021293751 @default.
• W2945235910 creator A5030011912 @default.
• W2945235910 creator A5041704389 @default.
• W2945235910 creator A5046214153 @default.
• W2945235910 creator A5054714140 @default.
• W2945235910 creator A5075568104 @default.
• W2945235910 creator A5090685065 @default.
• W2945235910 date "2019-05-17" @default.
• W2945235910 modified "2023-10-03" @default.
• W2945235910 title "Proteomics Research on the Protective Effect of Mangiferin on H9C2 Cell Injury Induced by H2O2" @default.
• W2945235910 cites W1906240697 @default.
• W2945235910 cites W1935332043 @default.
• W2945235910 cites W1944470698 @default.
• W2945235910 cites W1965970124 @default.
• W2945235910 cites W1967600689 @default.
• W2945235910 cites W1974539684 @default.
• W2945235910 cites W1977178308 @default.
• W2945235910 cites W1981550821 @default.
• W2945235910 cites W1983187303 @default.
• W2945235910 cites W1986366581 @default.
• W2945235910 cites W1991113353 @default.
• W2945235910 cites W1999312816 @default.
• W2945235910 cites W2006084919 @default.
• W2945235910 cites W2007917384 @default.
• W2945235910 cites W2008417238 @default.
• W2945235910 cites W2010217891 @default.
• W2945235910 cites W2011225986 @default.
• W2945235910 cites W2023099428 @default.
• W2945235910 cites W2035609051 @default.
• W2945235910 cites W2035769351 @default.
• W2945235910 cites W2040493825 @default.
• W2945235910 cites W2051395985 @default.
• W2945235910 cites W2055202676 @default.
• W2945235910 cites W2057622336 @default.
• W2945235910 cites W2060790071 @default.
• W2945235910 cites W2067582236 @default.
• W2945235910 cites W2075109383 @default.
• W2945235910 cites W2075835329 @default.
• W2945235910 cites W2090526906 @default.
• W2945235910 cites W2119296764 @default.
• W2945235910 cites W2133309314 @default.
• W2945235910 cites W2134496342 @default.
• W2945235910 cites W2135041781 @default.
• W2945235910 cites W2141819645 @default.
• W2945235910 cites W2146885685 @default.
• W2945235910 cites W2158728808 @default.
• W2945235910 cites W2170541543 @default.
• W2945235910 cites W2179583283 @default.
• W2945235910 cites W2276751048 @default.
• W2945235910 cites W2278016680 @default.
• W2945235910 cites W2282716670 @default.
• W2945235910 cites W2282819630 @default.
• W2945235910 cites W2340103530 @default.
• W2945235910 cites W2353072738 @default.
• W2945235910 cites W2435888494 @default.
• W2945235910 cites W2528540152 @default.
• W2945235910 cites W2567440464 @default.
• W2945235910 cites W2743549780 @default.
• W2945235910 cites W2749551596 @default.
• W2945235910 cites W2755015406 @default.
• W2945235910 doi "https://doi.org/10.3390/molecules24101911" @default.
• W2945235910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6572523" @default.
• W2945235910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31109015" @default.
• W2945235910 hasPublicationYear "2019" @default.
• W2945235910 type Work @default.
• W2945235910 sameAs 2945235910 @default.
• W2945235910 citedByCount "10" @default.
• W2945235910 countsByYear W29452359102019 @default.
• W2945235910 countsByYear W29452359102020 @default.
• W2945235910 countsByYear W29452359102021 @default.
• W2945235910 countsByYear W29452359102022 @default.
• W2945235910 countsByYear W29452359102023 @default.
• W2945235910 crossrefType "journal-article" @default.
• W2945235910 hasAuthorship W2945235910A5012219112 @default.
• W2945235910 hasAuthorship W2945235910A5015195367 @default.
• W2945235910 hasAuthorship W2945235910A5021293751 @default.
• W2945235910 hasAuthorship W2945235910A5030011912 @default.
• W2945235910 hasAuthorship W2945235910A5041704389 @default.
• W2945235910 hasAuthorship W2945235910A5046214153 @default.
• W2945235910 hasAuthorship W2945235910A5054714140 @default.
• W2945235910 hasAuthorship W2945235910A5075568104 @default.
• W2945235910 hasAuthorship W2945235910A5090685065 @default.
• W2945235910 hasBestOaLocation W29452359101 @default.
• W2945235910 hasConcept C104317684 @default.
• W2945235910 hasConcept C150194340 @default.
• W2945235910 hasConcept C152724338 @default.
• W2945235910 hasConcept C162317418 @default.
• W2945235910 hasConcept C185592680 @default.
• W2945235910 hasConcept C20251656 @default.
• W2945235910 hasConcept C2776151105 @default.
• W2945235910 hasConcept C2776991927 @default.
• W2945235910 hasConcept C2777781930 @default.
• W2945235910 hasConcept C2778004101 @default.
• W2945235910 hasConcept C46111723 @default.

• next