Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945248423> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2945248423 endingPage "396" @default.
- W2945248423 startingPage "391" @default.
- W2945248423 abstract "The ability to assess the hemostatic effect of the direct oral anticoagulant (DOACs) may be valuable in clinical situations such as bleeding or thrombosis, before urgent surgery, or reversal of anticoagulation. We sought to assess the anticoagulant effect of DOACs with the new-generation fully automated thrombelastograph TEG 6s using resonance-frequency viscoelasticity measurements and disposable multichannel microfluidic cartridges.A single dose of oral dabigatran 150 mg, rivaroxaban 20 mg, or apixaban 5 mg was given to 9 healthy males. Phlebotomy was performed at 0, 1, and 3 hours after administration of DOAC. TEG parameters were measured using TEG _6s. Concentrations of DOACs were measured using chromogenic assays. The TEG parameters were correlated to the DOAC concentrations.The reaction time (R) demonstrated the strongest response to DOAC intake. There were no correlations between other TEG parameters and DOAC concentrations. Using the direct thrombin inhibitor (DTI) channel, R was significantly correlated with dabigatran levels (r = 0.94, P < 0.0001). Using the anti-factor Xa (AFXa) channel, R was significantly correlated with rivaroxaban and apixaban levels (r = 0.93 and r = 0.83, respectively; P < 0.0001 for both). R >2.5 minutes for dabigatran (DTI channel), >2.5 minutes for apixaban, and >1.8 minutes for rivaroxaban (AFXa channel) were associated with 100% sensitivity and ≥ 90% specificity to detect DOAC levels of ≥ 50 ng/mL.We have demonstrated that TEG _6s R has significant correlation with DOAC blood concentrations and has potential for monitoring the DOAC's effect on hemostasis with reasonable sensitivity in the small sample analyzed. This novel technology is easy to use on a small volume of whole blood without requiring a specialized laboratory. Further study is warranted to correlate R with clinical outcomes." @default.
- W2945248423 created "2019-05-29" @default.
- W2945248423 creator A5062792548 @default.
- W2945248423 creator A5065767693 @default.
- W2945248423 creator A5088006074 @default.
- W2945248423 date "2019-07-01" @default.
- W2945248423 modified "2023-10-17" @default.
- W2945248423 title "Fully automated thromboelastograph TEG 6s to measure anticoagulant effects of direct oral anticoagulants in healthy male volunteers" @default.
- W2945248423 cites W1547546593 @default.
- W2945248423 cites W1991318743 @default.
- W2945248423 cites W2026648151 @default.
- W2945248423 cites W2052740401 @default.
- W2945248423 cites W2096324272 @default.
- W2945248423 cites W2140475678 @default.
- W2945248423 cites W2158014557 @default.
- W2945248423 cites W2162802146 @default.
- W2945248423 cites W2194419520 @default.
- W2945248423 cites W2198635349 @default.
- W2945248423 cites W2334118233 @default.
- W2945248423 cites W2411341066 @default.
- W2945248423 cites W2417660540 @default.
- W2945248423 cites W2594877709 @default.
- W2945248423 cites W2738356922 @default.
- W2945248423 cites W2755375976 @default.
- W2945248423 cites W2769760280 @default.
- W2945248423 cites W2800902847 @default.
- W2945248423 cites W2808974366 @default.
- W2945248423 cites W2945248423 @default.
- W2945248423 doi "https://doi.org/10.1002/rth2.12206" @default.
- W2945248423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6611480" @default.
- W2945248423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31294326" @default.
- W2945248423 hasPublicationYear "2019" @default.
- W2945248423 type Work @default.
- W2945248423 sameAs 2945248423 @default.
- W2945248423 citedByCount "37" @default.
- W2945248423 countsByYear W29452484232020 @default.
- W2945248423 countsByYear W29452484232021 @default.
- W2945248423 countsByYear W29452484232022 @default.
- W2945248423 countsByYear W29452484232023 @default.
- W2945248423 crossrefType "journal-article" @default.
- W2945248423 hasAuthorship W2945248423A5062792548 @default.
- W2945248423 hasAuthorship W2945248423A5065767693 @default.
- W2945248423 hasAuthorship W2945248423A5088006074 @default.
- W2945248423 hasBestOaLocation W29452484231 @default.
- W2945248423 hasConcept C126322002 @default.
- W2945248423 hasConcept C2776301958 @default.
- W2945248423 hasConcept C2778205648 @default.
- W2945248423 hasConcept C2778661090 @default.
- W2945248423 hasConcept C2778810321 @default.
- W2945248423 hasConcept C2779161974 @default.
- W2945248423 hasConcept C2780638905 @default.
- W2945248423 hasConcept C42219234 @default.
- W2945248423 hasConcept C71924100 @default.
- W2945248423 hasConcept C98274493 @default.
- W2945248423 hasConceptScore W2945248423C126322002 @default.
- W2945248423 hasConceptScore W2945248423C2776301958 @default.
- W2945248423 hasConceptScore W2945248423C2778205648 @default.
- W2945248423 hasConceptScore W2945248423C2778661090 @default.
- W2945248423 hasConceptScore W2945248423C2778810321 @default.
- W2945248423 hasConceptScore W2945248423C2779161974 @default.
- W2945248423 hasConceptScore W2945248423C2780638905 @default.
- W2945248423 hasConceptScore W2945248423C42219234 @default.
- W2945248423 hasConceptScore W2945248423C71924100 @default.
- W2945248423 hasConceptScore W2945248423C98274493 @default.
- W2945248423 hasIssue "3" @default.
- W2945248423 hasLocation W29452484231 @default.
- W2945248423 hasLocation W29452484232 @default.
- W2945248423 hasLocation W29452484233 @default.
- W2945248423 hasLocation W29452484234 @default.
- W2945248423 hasLocation W29452484235 @default.
- W2945248423 hasOpenAccess W2945248423 @default.
- W2945248423 hasPrimaryLocation W29452484231 @default.
- W2945248423 hasRelatedWork W1436836526 @default.
- W2945248423 hasRelatedWork W1975219299 @default.
- W2945248423 hasRelatedWork W2030888547 @default.
- W2945248423 hasRelatedWork W2046188252 @default.
- W2945248423 hasRelatedWork W2057947946 @default.
- W2945248423 hasRelatedWork W2083901189 @default.
- W2945248423 hasRelatedWork W2093259736 @default.
- W2945248423 hasRelatedWork W2134062404 @default.
- W2945248423 hasRelatedWork W2523933248 @default.
- W2945248423 hasRelatedWork W4292463656 @default.
- W2945248423 hasVolume "3" @default.
- W2945248423 isParatext "false" @default.
- W2945248423 isRetracted "false" @default.
- W2945248423 magId "2945248423" @default.
- W2945248423 workType "article" @default.