FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945260851> ?p ?o ?g. }

• W2945260851 abstract "Oral squamous cell carcinoma (OSCC) is a common malignancy of the oral and maxillofacial regions. MicroRNAs (miRs) are a group of endogenous small noncoding RNAs that inhibit gene expression by binding to the mRNA of target genes, and serve important roles in numerous biological processes. Reverse transcription‑quantitative polymerase chain reaction and western blotting were used to detect gene and protein expression levels, respectively. Cell proliferation, migration and invasion were detected using MTT, wound healing and Matrigel assays, respectively. The association between miR‑148a and human leukocyte antigen‑G (HLA‑G) was analyzed using Targetscan and Luciferase reporter assays. In the present study, miR‑148a was revealed to be significantly downregulated in OSCC cells. To further investigate the functions of miR‑148a in OSCC, the viability, migration, and invasive abilities of SCC‑9 cells were investigated following transfection with miR‑148a mimics or miR‑148a inhibitor. It was revealed that transfection with miR‑148a mimics significantly reduced the viability, migration and invasion of cells, whereas miR‑148a inhibitor significantly enhanced these properties. In addition, HLA‑G was identified as a direct target of miR‑148a and demonstrated to be downregulated in OSCC cells. Furthermore, it was revealed that transfection with miR‑148a mimics decreased the expression levels of HLA‑G mRNA and protein in SCC‑9 cells, whereas transfection with miR‑148a inhibitor increased the expression of HLA‑G mRNA and protein. The results indicated that there was an association between miR‑148a and HLA‑G expression, and suggested that miR‑148a may be a potential target in the treatment of OSCC." @default.
• W2945260851 created "2019-05-29" @default.
• W2945260851 creator A5006616499 @default.
• W2945260851 creator A5030362872 @default.
• W2945260851 creator A5075877965 @default.
• W2945260851 date "2019-05-22" @default.
• W2945260851 modified "2023-09-24" @default.
• W2945260851 title "miR‑148a modulates the viability, migration and invasion of oral squamous cell carcinoma cells by regulating HLA‑G expression" @default.
• W2945260851 cites W144423133 @default.
• W2945260851 cites W144482947 @default.
• W2945260851 cites W1608533935 @default.
• W2945260851 cites W1648301895 @default.
• W2945260851 cites W1817446955 @default.
• W2945260851 cites W1916852097 @default.
• W2945260851 cites W1951233870 @default.
• W2945260851 cites W1968324115 @default.
• W2945260851 cites W1984386869 @default.
• W2945260851 cites W2002995168 @default.
• W2945260851 cites W2005401913 @default.
• W2945260851 cites W2018243124 @default.
• W2945260851 cites W2036792690 @default.
• W2945260851 cites W2075091220 @default.
• W2945260851 cites W2079479637 @default.
• W2945260851 cites W2086752428 @default.
• W2945260851 cites W2087045096 @default.
• W2945260851 cites W2094506333 @default.
• W2945260851 cites W2095203473 @default.
• W2945260851 cites W2098677755 @default.
• W2945260851 cites W2107277218 @default.
• W2945260851 cites W2117497316 @default.
• W2945260851 cites W2127746767 @default.
• W2945260851 cites W2149685907 @default.
• W2945260851 cites W2151912077 @default.
• W2945260851 cites W2151922790 @default.
• W2945260851 cites W2192080449 @default.
• W2945260851 cites W2199347453 @default.
• W2945260851 cites W2301890235 @default.
• W2945260851 cites W2324578148 @default.
• W2945260851 cites W2343231291 @default.
• W2945260851 cites W2395301571 @default.
• W2945260851 cites W2412775319 @default.
• W2945260851 cites W2427154343 @default.
• W2945260851 cites W2464266545 @default.
• W2945260851 cites W2502717543 @default.
• W2945260851 cites W2508694971 @default.
• W2945260851 cites W2581825526 @default.
• W2945260851 cites W2594354909 @default.
• W2945260851 cites W2594892804 @default.
• W2945260851 cites W2597632520 @default.
• W2945260851 cites W2625509882 @default.
• W2945260851 cites W2747157083 @default.
• W2945260851 cites W2770825413 @default.
• W2945260851 cites W2806454743 @default.
• W2945260851 cites W2898382408 @default.
• W2945260851 cites W2916760041 @default.
• W2945260851 cites W2918315214 @default.
• W2945260851 cites W3023299375 @default.
• W2945260851 cites W972706221 @default.
• W2945260851 doi "https://doi.org/10.3892/mmr.2019.10280" @default.
• W2945260851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6580030" @default.
• W2945260851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31180532" @default.
• W2945260851 hasPublicationYear "2019" @default.
• W2945260851 type Work @default.
• W2945260851 sameAs 2945260851 @default.
• W2945260851 citedByCount "7" @default.
• W2945260851 countsByYear W29452608512020 @default.
• W2945260851 countsByYear W29452608512021 @default.
• W2945260851 countsByYear W29452608512022 @default.
• W2945260851 countsByYear W29452608512023 @default.
• W2945260851 crossrefType "journal-article" @default.
• W2945260851 hasAuthorship W2945260851A5006616499 @default.
• W2945260851 hasAuthorship W2945260851A5030362872 @default.
• W2945260851 hasAuthorship W2945260851A5075877965 @default.
• W2945260851 hasBestOaLocation W29452608511 @default.
• W2945260851 hasConcept C104317684 @default.
• W2945260851 hasConcept C11957725 @default.
• W2945260851 hasConcept C145059251 @default.
• W2945260851 hasConcept C1491633281 @default.
• W2945260851 hasConcept C153911025 @default.
• W2945260851 hasConcept C2776415932 @default.
• W2945260851 hasConcept C2781018059 @default.
• W2945260851 hasConcept C29537977 @default.
• W2945260851 hasConcept C502942594 @default.
• W2945260851 hasConcept C53227056 @default.
• W2945260851 hasConcept C54009773 @default.
• W2945260851 hasConcept C54355233 @default.
• W2945260851 hasConcept C55493867 @default.
• W2945260851 hasConcept C81885089 @default.
• W2945260851 hasConcept C86803240 @default.
• W2945260851 hasConceptScore W2945260851C104317684 @default.
• W2945260851 hasConceptScore W2945260851C11957725 @default.
• W2945260851 hasConceptScore W2945260851C145059251 @default.
• W2945260851 hasConceptScore W2945260851C1491633281 @default.
• W2945260851 hasConceptScore W2945260851C153911025 @default.
• W2945260851 hasConceptScore W2945260851C2776415932 @default.
• W2945260851 hasConceptScore W2945260851C2781018059 @default.
• W2945260851 hasConceptScore W2945260851C29537977 @default.
• W2945260851 hasConceptScore W2945260851C502942594 @default.
• W2945260851 hasConceptScore W2945260851C53227056 @default.
• W2945260851 hasConceptScore W2945260851C54009773 @default.

• next