FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945283471> ?p ?o ?g. }

• W2945283471 endingPage "147" @default.
• W2945283471 startingPage "137" @default.
• W2945283471 abstract "The Janus-activated kinase (JAK) family together with signal transducer and activator of transcription (STAT) signaling pathway has a key role in regulating the expression and function of many inflammatory cytokines. This has led to the discovery of JAK inhibitors for the treatment of inflammatory diseases, some of them already in the market. Considering the adverse effects associated with JAK inhibition by oral route, we wanted to explore whether JAK inhibition by inhaled route is enough to inhibit airway inflammation. The aim of this study was to characterize the enzymatic and cellular potency and the selectivity of LAS194046, a novel JAK inhibitor, compared with the reference compounds ruxolitinib and tofacitinib. The efficacy of this new JAK inhibitor is described in a model of ovalbumin (OVA)-induced airway inflammation in Brown Norway rats by inhaled administration. As potential markers of target engagement, we assessed the effect of LAS194046 on the STAT activation state. LAS194046 is a selective inhaled pan-JAK inhibitor that reduces allergen-induced airway inflammation, late asthmatic response, and phosphor-STAT activation in the rat OVA model. Our results show that topical inhibition of JAK in the lung, without relevant systemic exposure, is sufficient to reduce lung inflammation and improve lung function in a rat asthma model. In summary, JAK-STAT pathway inhibition by inhaled route constitutes a promising therapeutic option for lung inflammatory diseases." @default.
• W2945283471 created "2019-05-29" @default.
• W2945283471 creator A5011244775 @default.
• W2945283471 creator A5020672702 @default.
• W2945283471 creator A5020849878 @default.
• W2945283471 creator A5027915545 @default.
• W2945283471 creator A5033902407 @default.
• W2945283471 creator A5036394320 @default.
• W2945283471 creator A5051208421 @default.
• W2945283471 creator A5052447304 @default.
• W2945283471 creator A5067074266 @default.
• W2945283471 creator A5078648343 @default.
• W2945283471 creator A5083045977 @default.
• W2945283471 creator A5090315120 @default.
• W2945283471 date "2019-05-13" @default.
• W2945283471 modified "2023-10-02" @default.
• W2945283471 title "Novel Inhaled Pan-JAK Inhibitor, LAS194046, Reduces Allergen-Induced Airway Inflammation, Late Asthmatic Response, and pSTAT Activation in Brown Norway Rats" @default.
• W2945283471 cites W1483308173 @default.
• W2945283471 cites W1964095838 @default.
• W2945283471 cites W1984145469 @default.
• W2945283471 cites W1991688187 @default.
• W2945283471 cites W1995629248 @default.
• W2945283471 cites W1999218213 @default.
• W2945283471 cites W2001519848 @default.
• W2945283471 cites W2019531367 @default.
• W2945283471 cites W2041286264 @default.
• W2945283471 cites W2042960115 @default.
• W2945283471 cites W2054717635 @default.
• W2945283471 cites W2067626809 @default.
• W2945283471 cites W2079645940 @default.
• W2945283471 cites W2091265741 @default.
• W2945283471 cites W2095543695 @default.
• W2945283471 cites W2100041032 @default.
• W2945283471 cites W2100772783 @default.
• W2945283471 cites W2117926449 @default.
• W2945283471 cites W2125522165 @default.
• W2945283471 cites W2132173287 @default.
• W2945283471 cites W2134017175 @default.
• W2945283471 cites W2134646045 @default.
• W2945283471 cites W2135424108 @default.
• W2945283471 cites W2136836875 @default.
• W2945283471 cites W2146052816 @default.
• W2945283471 cites W2149189075 @default.
• W2945283471 cites W2152532651 @default.
• W2945283471 cites W2157748566 @default.
• W2945283471 cites W2159272088 @default.
• W2945283471 cites W2164486346 @default.
• W2945283471 cites W2165495560 @default.
• W2945283471 cites W2166206822 @default.
• W2945283471 cites W2170480610 @default.
• W2945283471 cites W2521310721 @default.
• W2945283471 cites W2529532071 @default.
• W2945283471 cites W2565360718 @default.
• W2945283471 cites W2568766196 @default.
• W2945283471 cites W2593565645 @default.
• W2945283471 cites W2604581907 @default.
• W2945283471 cites W2787696154 @default.
• W2945283471 cites W2795748093 @default.
• W2945283471 cites W2795837720 @default.
• W2945283471 cites W2799581227 @default.
• W2945283471 cites W2883700530 @default.
• W2945283471 doi "https://doi.org/10.1124/jpet.119.256263" @default.
• W2945283471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31085698" @default.
• W2945283471 hasPublicationYear "2019" @default.
• W2945283471 type Work @default.
• W2945283471 sameAs 2945283471 @default.
• W2945283471 citedByCount "24" @default.
• W2945283471 countsByYear W29452834712020 @default.
• W2945283471 countsByYear W29452834712021 @default.
• W2945283471 countsByYear W29452834712022 @default.
• W2945283471 countsByYear W29452834712023 @default.
• W2945283471 crossrefType "journal-article" @default.
• W2945283471 hasAuthorship W2945283471A5011244775 @default.
• W2945283471 hasAuthorship W2945283471A5020672702 @default.
• W2945283471 hasAuthorship W2945283471A5020849878 @default.
• W2945283471 hasAuthorship W2945283471A5027915545 @default.
• W2945283471 hasAuthorship W2945283471A5033902407 @default.
• W2945283471 hasAuthorship W2945283471A5036394320 @default.
• W2945283471 hasAuthorship W2945283471A5051208421 @default.
• W2945283471 hasAuthorship W2945283471A5052447304 @default.
• W2945283471 hasAuthorship W2945283471A5067074266 @default.
• W2945283471 hasAuthorship W2945283471A5078648343 @default.
• W2945283471 hasAuthorship W2945283471A5083045977 @default.
• W2945283471 hasAuthorship W2945283471A5090315120 @default.
• W2945283471 hasBestOaLocation W29452834711 @default.
• W2945283471 hasConcept C112392421 @default.
• W2945283471 hasConcept C126322002 @default.
• W2945283471 hasConcept C145430368 @default.
• W2945283471 hasConcept C157333092 @default.
• W2945283471 hasConcept C170493617 @default.
• W2945283471 hasConcept C171958077 @default.
• W2945283471 hasConcept C185592680 @default.
• W2945283471 hasConcept C191732599 @default.
• W2945283471 hasConcept C203014093 @default.
• W2945283471 hasConcept C2776112149 @default.
• W2945283471 hasConcept C2776914184 @default.
• W2945283471 hasConcept C2776946954 @default.
• W2945283471 hasConcept C2777575956 @default.

• next