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- W2945292787 abstract "Mammalian arenaviruses are zoonotic viruses that cause asymptomatic and persistent infections in their rodent hosts but may produce severe and lethal hemorrhagic fevers in humans. Currently, there are neither effective therapeutic options nor effective vaccines for viral hemorrhagic fevers caused by human-pathogenic arenaviruses, except the vaccine Candid no. 1 against Argentine hemorrhagic fever (AHF), licensed for human use in areas of endemicity in Argentina. Since arenaviruses remain a severe threat to global public health, more in-depth knowledge of their replication mechanisms would improve our ability to fight these viruses. Autophagy is a lysosomal degradative pathway involved in maintaining cellular homeostasis, representing powerful anti-infective machinery. We show, for the first time for a member of the family Arenaviridae , a proviral role of autophagy in JUNV infection, providing new knowledge in the field of host-virus interaction. Therefore, modulation of virus-induced autophagy could be used as a strategy to block arenavirus infections." @default.
- W2945292787 created "2019-05-29" @default.
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- W2945292787 date "2019-08-01" @default.
- W2945292787 modified "2023-10-14" @default.
- W2945292787 title "Junín Virus Promotes Autophagy To Facilitate the Virus Life Cycle" @default.
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- W2945292787 doi "https://doi.org/10.1128/jvi.02307-18" @default.
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