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- W2945301121 abstract "Treatment strategies for dystonia depend on the focal, segmental or generalized distribution of symptoms. Chemodenervation with botulinum toxin remains the treatment of choice for focal- or select-body regions in generalized and segmental dystonia. A potentially longer acting formulation of botulinum toxin is being investigated besides the currently available formulations. Electromyography increases toxin injection accuracy and may reduce injection number, frequency, side effects and costs by identifying dystonic muscle activity. Oral anticholinergics, baclofen and clonazepam are used off-label, but novel drugs in development include sodium oxybate, zonisamide and perampanel. Characterizing dystonia as a sensorimotor circuit disorder has prompted the use of noninvasive neuromodulation procedures. These techniques need further study but simultaneous rehabilitation techniques appear to also improve outcomes. Pallidal deep-brain stimulation is beneficial for medication-refractory primary generalized and possibly focal dystonia such as cervical dystonia. Certain genetic conditions are amenable to specific therapies and future gene-targeted therapies could benefit selected dystonia patients." @default.
- W2945301121 created "2019-05-29" @default.
- W2945301121 creator A5048688457 @default.
- W2945301121 creator A5064384597 @default.
- W2945301121 creator A5070130684 @default.
- W2945301121 date "2019-06-01" @default.
- W2945301121 modified "2023-10-14" @default.
- W2945301121 title "Update on current and emerging therapies for dystonia" @default.
- W2945301121 cites W1500704944 @default.
- W2945301121 cites W1537305889 @default.
- W2945301121 cites W1844973750 @default.
- W2945301121 cites W187010169 @default.
- W2945301121 cites W1891730382 @default.
- W2945301121 cites W1891756794 @default.
- W2945301121 cites W1964176673 @default.
- W2945301121 cites W1973178783 @default.
- W2945301121 cites W1980996179 @default.
- W2945301121 cites W1984348446 @default.
- W2945301121 cites W1987061649 @default.
- W2945301121 cites W1990344743 @default.
- W2945301121 cites W1996003287 @default.
- W2945301121 cites W1997959034 @default.
- W2945301121 cites W1999969254 @default.
- W2945301121 cites W2000362939 @default.
- W2945301121 cites W2006468011 @default.
- W2945301121 cites W2023609209 @default.
- W2945301121 cites W2029612341 @default.
- W2945301121 cites W2058388133 @default.
- W2945301121 cites W2076562195 @default.
- W2945301121 cites W2079890482 @default.
- W2945301121 cites W2082224780 @default.
- W2945301121 cites W2093409335 @default.
- W2945301121 cites W2098041519 @default.
- W2945301121 cites W2102598726 @default.
- W2945301121 cites W2114832823 @default.
- W2945301121 cites W2131134103 @default.
- W2945301121 cites W2136139557 @default.
- W2945301121 cites W2137643237 @default.
- W2945301121 cites W2139472641 @default.
- W2945301121 cites W2141712723 @default.
- W2945301121 cites W2145175966 @default.
- W2945301121 cites W2147980755 @default.
- W2945301121 cites W2149802371 @default.
- W2945301121 cites W2154628144 @default.
- W2945301121 cites W2161719114 @default.
- W2945301121 cites W2169147129 @default.
- W2945301121 cites W2213065589 @default.
- W2945301121 cites W2258466720 @default.
- W2945301121 cites W2312534761 @default.
- W2945301121 cites W2332134875 @default.
- W2945301121 cites W2337991653 @default.
- W2945301121 cites W2397549618 @default.
- W2945301121 cites W2400394072 @default.
- W2945301121 cites W2405148204 @default.
- W2945301121 cites W2411916856 @default.
- W2945301121 cites W2505326305 @default.
- W2945301121 cites W2546552856 @default.
- W2945301121 cites W2548237762 @default.
- W2945301121 cites W2556957096 @default.
- W2945301121 cites W2571824852 @default.
- W2945301121 cites W2582022757 @default.
- W2945301121 cites W2585852541 @default.
- W2945301121 cites W2587156656 @default.
- W2945301121 cites W2589888331 @default.
- W2945301121 cites W2596975699 @default.
- W2945301121 cites W2607267818 @default.
- W2945301121 cites W2609418742 @default.
- W2945301121 cites W2625047938 @default.
- W2945301121 cites W2679531392 @default.
- W2945301121 cites W2735580835 @default.
- W2945301121 cites W2739887708 @default.
- W2945301121 cites W2740733621 @default.
- W2945301121 cites W2751175118 @default.
- W2945301121 cites W2752680847 @default.
- W2945301121 cites W2755959583 @default.
- W2945301121 cites W2763178859 @default.
- W2945301121 cites W2765295927 @default.
- W2945301121 cites W2765387550 @default.
- W2945301121 cites W2767128263 @default.
- W2945301121 cites W2769520101 @default.
- W2945301121 cites W2774452580 @default.
- W2945301121 cites W2777311185 @default.
- W2945301121 cites W2783608857 @default.
- W2945301121 cites W2791001182 @default.
- W2945301121 cites W2792984595 @default.
- W2945301121 cites W2793234123 @default.
- W2945301121 cites W2795686876 @default.
- W2945301121 cites W2801534436 @default.
- W2945301121 cites W2801757185 @default.
- W2945301121 cites W2891206583 @default.
- W2945301121 cites W2898454277 @default.
- W2945301121 cites W2900976928 @default.
- W2945301121 cites W73407941 @default.
- W2945301121 cites W784541403 @default.
- W2945301121 doi "https://doi.org/10.2217/nmt-2018-0047" @default.
- W2945301121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31117876" @default.
- W2945301121 hasPublicationYear "2019" @default.
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