Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945305468> ?p ?o ?g. }
- W2945305468 endingPage "733" @default.
- W2945305468 startingPage "733" @default.
- W2945305468 abstract "Several studies suggest that 5-alpha reductase inhibitors (5ARIs) may be associated with elevated risk of cardiovascular disease (CVD). We investigated the association of 5ARI exposure and CVD incidence using the National Health Insurance Service-Health Screening Cohort, a nationally representative population-based sample of Koreans. We calculated the 4-year cumulative exposure to 5ARI for 215,003 men without prior 5ARI use. Participants were followed from January 1st, 2008 to December 31st, 2015. A subcohort of newly diagnosed benign prostatic hyperplasia (BPH) patients during 2004–2010 was also analyzed. The primary study outcome was CVD and secondary outcomes were myocardial infarction (MI) or stroke. Hazard ratios (HRs) were estimated using Cox proportional hazards models adjusted for conventional risk factors. In both the main cohort and BPH subcohort, the use of any 5ARI did not increase the risk of cardiovascular disease (HR = 1.06; 95% CI = 0.91–1.23; HR = 0.95; 95% CI = 0.88–1.03; respectively). Furthermore, as an unexpected finding, a dose-analysis among the BPH subcohort showed that the highest tertile of 5ARI exposure reduced the risk of CVD (HR = 0.82; 95% CI = 0.72–0.92; p-trend = 0.001), MI (HR = 0.69; 95% CI = 0.50–0.95), and stroke (HR = 0.84; 95% CI = 0.72–0.98) compared to non-users. Among men and BPH patients, 5ARI did not increase the risk of CVD. Among BPH patients, 5ARI use may reduce the risk CVD." @default.
- W2945305468 created "2019-05-29" @default.
- W2945305468 creator A5035047849 @default.
- W2945305468 creator A5066036654 @default.
- W2945305468 creator A5073951803 @default.
- W2945305468 creator A5087803692 @default.
- W2945305468 date "2019-05-22" @default.
- W2945305468 modified "2023-09-27" @default.
- W2945305468 title "Cardiovascular Safety and Possible Benefit of a 5-Alpha Reductase Inhibitor among Benign Prostatic Hyperplasia Patients, A Nationally Representative Cohort of Korean Men" @default.
- W2945305468 cites W1964632278 @default.
- W2945305468 cites W1969828880 @default.
- W2945305468 cites W1973572075 @default.
- W2945305468 cites W1982313306 @default.
- W2945305468 cites W1999845279 @default.
- W2945305468 cites W2004150536 @default.
- W2945305468 cites W2005687876 @default.
- W2945305468 cites W2028936274 @default.
- W2945305468 cites W2033562626 @default.
- W2945305468 cites W2045398130 @default.
- W2945305468 cites W2051592657 @default.
- W2945305468 cites W2062431789 @default.
- W2945305468 cites W2067890225 @default.
- W2945305468 cites W2087107662 @default.
- W2945305468 cites W2088217716 @default.
- W2945305468 cites W2089648710 @default.
- W2945305468 cites W2097930057 @default.
- W2945305468 cites W2110941928 @default.
- W2945305468 cites W2128543455 @default.
- W2945305468 cites W2140905531 @default.
- W2945305468 cites W2149914864 @default.
- W2945305468 cites W2152123220 @default.
- W2945305468 cites W2155279970 @default.
- W2945305468 cites W2155530804 @default.
- W2945305468 cites W2544991555 @default.
- W2945305468 cites W2596675526 @default.
- W2945305468 cites W2610994046 @default.
- W2945305468 cites W2757321799 @default.
- W2945305468 cites W3135529189 @default.
- W2945305468 cites W4231246543 @default.
- W2945305468 cites W4362207783 @default.
- W2945305468 doi "https://doi.org/10.3390/jcm8050733" @default.
- W2945305468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6572349" @default.
- W2945305468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31121994" @default.
- W2945305468 hasPublicationYear "2019" @default.
- W2945305468 type Work @default.
- W2945305468 sameAs 2945305468 @default.
- W2945305468 citedByCount "1" @default.
- W2945305468 countsByYear W29453054682021 @default.
- W2945305468 crossrefType "journal-article" @default.
- W2945305468 hasAuthorship W2945305468A5035047849 @default.
- W2945305468 hasAuthorship W2945305468A5066036654 @default.
- W2945305468 hasAuthorship W2945305468A5073951803 @default.
- W2945305468 hasAuthorship W2945305468A5087803692 @default.
- W2945305468 hasBestOaLocation W29453054681 @default.
- W2945305468 hasConcept C120665830 @default.
- W2945305468 hasConcept C121332964 @default.
- W2945305468 hasConcept C126322002 @default.
- W2945305468 hasConcept C127413603 @default.
- W2945305468 hasConcept C201903717 @default.
- W2945305468 hasConcept C207103383 @default.
- W2945305468 hasConcept C2780645631 @default.
- W2945305468 hasConcept C2908647359 @default.
- W2945305468 hasConcept C29456083 @default.
- W2945305468 hasConcept C44249647 @default.
- W2945305468 hasConcept C500558357 @default.
- W2945305468 hasConcept C50382708 @default.
- W2945305468 hasConcept C61511704 @default.
- W2945305468 hasConcept C71924100 @default.
- W2945305468 hasConcept C72563966 @default.
- W2945305468 hasConcept C78519656 @default.
- W2945305468 hasConcept C99454951 @default.
- W2945305468 hasConceptScore W2945305468C120665830 @default.
- W2945305468 hasConceptScore W2945305468C121332964 @default.
- W2945305468 hasConceptScore W2945305468C126322002 @default.
- W2945305468 hasConceptScore W2945305468C127413603 @default.
- W2945305468 hasConceptScore W2945305468C201903717 @default.
- W2945305468 hasConceptScore W2945305468C207103383 @default.
- W2945305468 hasConceptScore W2945305468C2780645631 @default.
- W2945305468 hasConceptScore W2945305468C2908647359 @default.
- W2945305468 hasConceptScore W2945305468C29456083 @default.
- W2945305468 hasConceptScore W2945305468C44249647 @default.
- W2945305468 hasConceptScore W2945305468C500558357 @default.
- W2945305468 hasConceptScore W2945305468C50382708 @default.
- W2945305468 hasConceptScore W2945305468C61511704 @default.
- W2945305468 hasConceptScore W2945305468C71924100 @default.
- W2945305468 hasConceptScore W2945305468C72563966 @default.
- W2945305468 hasConceptScore W2945305468C78519656 @default.
- W2945305468 hasConceptScore W2945305468C99454951 @default.
- W2945305468 hasFunder F4320322120 @default.
- W2945305468 hasIssue "5" @default.
- W2945305468 hasLocation W29453054681 @default.
- W2945305468 hasLocation W29453054682 @default.
- W2945305468 hasLocation W29453054683 @default.
- W2945305468 hasLocation W29453054684 @default.
- W2945305468 hasOpenAccess W2945305468 @default.
- W2945305468 hasPrimaryLocation W29453054681 @default.
- W2945305468 hasRelatedWork W1516595110 @default.
- W2945305468 hasRelatedWork W2071306276 @default.