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• W2945306786 abstract "Mosquito-borne diseases are of global significance causing considerable morbidity and mortality throughout the world. Dengue virus (DENV; serotypes 1 to 4), a member of the Flavivirus genus of the Flaviviridae family, causes millions of infections annually. Development of a safe vaccine is hampered due to absence of cross-protection and increased risk in secondary infections due to antibody-mediated immune enhancement. Infection of vector mosquitoes with Wolbachia bacteria offers a novel countermeasure to suppress DENV transmission, but the mechanisms are poorly understood. In this study, the host transcription profiles and viral RNA sequences were analyzed in naive A. albopictus (C6/36) and w MelPop-C6/36 cells by RNAseq. Our results showed that the w MelPop symbiont caused profound changes in host transcription profiles and morphology of DENV2-infected C6/36 cells. Accumulation of several mutations throughout DENV2 RNA resulted in loss of infectivity of progeny virions. Our findings offer new insights into the mechanism of Wolbachia -mediated suppression of DENV transmission." @default.
• W2945306786 created "2019-05-29" @default.
• W2945306786 creator A5009894607 @default.
• W2945306786 creator A5011072132 @default.
• W2945306786 creator A5011726094 @default.
• W2945306786 creator A5069323728 @default.
• W2945306786 date "2019-08-01" @default.
• W2945306786 modified "2023-09-25" @default.
• W2945306786 title "Infection of Aedes albopictus Mosquito C6/36 Cells with the <i>w</i> Melpop Strain of <i>Wolbachia</i> Modulates Dengue Virus-Induced Host Cellular Transcripts and Induces Critical Sequence Alterations in the Dengue Viral Genome" @default.
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• W2945306786 doi "https://doi.org/10.1128/jvi.00581-19" @default.
• W2945306786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6639269" @default.
• W2945306786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31092581" @default.

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