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- W2945334414 abstract "There is extensive literature on PARP1, owing to the multiple functions of PARP1 for DNA repair, aging, chromatin remodeling and transcription, and to the successful clinical development of four PARP inhibitors. In this issue of Cancer Research, Wang and colleagues identified phosphatase 1 nuclear targeting subunit (PNUTS, also referred to as PP1R10) as a partner of PARP1 and demonstrated that PNUTS and PARP1 are interdependent for their recruitment to DNA damage sites. As PARP1 is a prominent target for cancer therapy and PNUTS has PARP-dependent as well as PARP1-independent activities, the findings of Wang and colleagues add insight into DNA repair mechanisms with potential application to drug targeting and precision therapy.See related article by Wang et al., p. 2526." @default.
- W2945334414 created "2019-05-29" @default.
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- W2945334414 date "2019-05-15" @default.
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- W2945334414 title "Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1" @default.
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- W2945334414 doi "https://doi.org/10.1158/0008-5472.can-19-0798" @default.
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