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W2945334907 abstract "Abstract Background Primary central nervous system lymphoma (PCNSL) is a rare form of extra-nodal non-Hodgkin lymphoma. PCNSL is a distinct subtype of non-Hodgkin lymphoma, with over 95% of tumors belonging to the diffuse large B-cell lymphoma (DLBCL) group. We have conducted a genome-wide association study (GWAS) on immunocompetent patients to address the possibility that common genetic variants influence the risk of developing PCNSL. Methods We performed a meta-analysis of 2 new GWASs of PCNSL totaling 475 cases and 1134 controls of European ancestry. To increase genomic resolution, we imputed >10 million single nucleotide polymorphisms using the 1000 Genomes Project combined with UK10K as reference. In addition we performed a transcription factor binding disruption analysis and investigated the patterns of local chromatin by Capture Hi-C data. Results We identified independent risk loci at 3p22.1 (rs41289586, ANO10, P = 2.17 × 10−8) and 6p25.3 near EXOC2 (rs116446171, P = 1.95 x 10−13). In contrast, the lack of an association between rs41289586 and DLBCL suggests distinct germline predisposition to PCNSL and DLBCL. We found looping chromatin interactions between noncoding regions at 6p25.3 (rs11646171) with the IRF4 promoter and at 8q24.21 (rs13254990) with the MYC promoter, both genes with strong relevance to B-cell tumorigenesis. Conclusion To our knowledge this is the first study providing insight into the genetic predisposition to PCNSL. Our findings represent an important step in defining the contribution of common genetic variation to the risk of developing PCNSL." @default.
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W2945334907 date "2019-05-17" @default.
W2945334907 modified "2023-10-16" @default.
W2945334907 title "A genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC Network study" @default.
W2945334907 cites W1511785830 @default.
W2945334907 cites W1568033114 @default.
W2945334907 cites W1605145036 @default.
W2945334907 cites W1903553665 @default.
W2945334907 cites W1952476462 @default.
W2945334907 cites W1967407054 @default.
W2945334907 cites W1970006069 @default.
W2945334907 cites W1975359970 @default.
W2945334907 cites W1980429964 @default.
W2945334907 cites W1989124191 @default.
W2945334907 cites W1989382586 @default.
W2945334907 cites W1991711136 @default.
W2945334907 cites W1992436001 @default.
W2945334907 cites W1995775226 @default.
W2945334907 cites W2003023281 @default.
W2945334907 cites W2003213259 @default.