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- W2945340622 abstract "ABSTRACT Cdc42 – a member of the small Rho GTPase family – regulates cell polarity across organisms from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial cells, through coordination of apical membrane morphogenesis, lumen formation and junction maturation. In parallel, work in yeast and Caenorhabditis elegans has provided important clues as to how this molecular switch can generate and regulate polarity through localized activation or inhibition, and cytoskeleton regulation. Recent studies have revealed how important and complex these regulations can be during epithelial morphogenesis. This complexity is mirrored by the fact that Cdc42 can exert its function through many effector proteins. In epithelial cells, these include atypical PKC (aPKC, also known as PKC-3), the P21-activated kinase (PAK) family, myotonic dystrophy-related Cdc42 binding kinase beta (MRCKβ, also known as CDC42BPB) and neural Wiskott–Aldrich syndrome protein (N-WASp, also known as WASL). Here, we review how the spatial regulation of Cdc42 promotes polarity and polarized morphogenesis of the plasma membrane, with a focus on the epithelial cell type." @default.
- W2945340622 created "2019-05-29" @default.
- W2945340622 creator A5018718631 @default.
- W2945340622 creator A5071455176 @default.
- W2945340622 creator A5088398061 @default.
- W2945340622 date "2019-05-15" @default.
- W2945340622 modified "2023-10-04" @default.
- W2945340622 title "Regulation of Cdc42 and its effectors in epithelial morphogenesis" @default.
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