FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945355958> ?p ?o ?g. }

• W2945355958 abstract "Abstract Although aging is considered to be an unavoidable event, recent experimental evidence suggests that the process can be delayed, counteracted, if not completely interrupted. Aging is the primary risk factor for the onset and development of neurodegenerative conditions like Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis. Intracellular calcium (Ca 2+ i ) dyshomeostasis, mitochondrial dysfunction, oxidative stress, and lipid dysregulation are critical factors that contribute to senescence-related processes. Ceramides, a class of sphingolipids involved in a wide array of biological functions, are important mediators of cellular senescence, but their role in neuronal aging is still largely unexplored. In this study, we investigated the effects of L-cycloserine (L-CS), an inhibitor of de novo ceramide biosynthesis, on the aging phenotype of cortical neurons that have been maintained in culture for 22 days, a setting employed as an in vitro model of cellular senescence. Our findings indicate that ‘aged’ neurons display, when compared to control cultures, overt dysregulation of cytosolic and subcellular [Ca 2+ ] i levels, mitochondrial dysfunction, increased reactive oxygen species generation, altered synaptic activity as well as the activation of neuronal death-related molecules. Treatment with L-CS (30 µM) positively affected the senescent phenotype, a result accompanied by recovery of neuronal [Ca 2+ ] i signaling, and reduction of mitochondrial dysfunction and reactive oxygen species generation. The results suggest that the de novo ceramide biosynthesis may represent a critical intermediate in the molecular and functional cascade leading to neuronal senescence. Our findings also identify ceramide biosynthesis inhibitors as promising pharmacological tools to decrease age-related neuronal dysfunctions." @default.
• W2945355958 created "2019-05-29" @default.
• W2945355958 creator A5009849937 @default.
• W2945355958 creator A5024277256 @default.
• W2945355958 creator A5029602658 @default.
• W2945355958 creator A5031213755 @default.
• W2945355958 creator A5031328280 @default.
• W2945355958 creator A5037946109 @default.
• W2945355958 creator A5041851539 @default.
• W2945355958 creator A5043729261 @default.
• W2945355958 creator A5052158405 @default.
• W2945355958 creator A5052183778 @default.
• W2945355958 creator A5091634152 @default.
• W2945355958 date "2019-05-23" @default.
• W2945355958 modified "2023-09-23" @default.
• W2945355958 title "Inhibition of<i>de novo</i>ceramide biosynthesis affects aging phenotype in an<i>in vitro</i>model of neuronal senescence" @default.
• W2945355958 cites W144454424 @default.
• W2945355958 cites W1455455345 @default.
• W2945355958 cites W1536483289 @default.
• W2945355958 cites W1703528746 @default.
• W2945355958 cites W1863276550 @default.
• W2945355958 cites W1966016110 @default.
• W2945355958 cites W1970827931 @default.
• W2945355958 cites W1974800178 @default.
• W2945355958 cites W1978813781 @default.
• W2945355958 cites W1985058290 @default.
• W2945355958 cites W1991003771 @default.
• W2945355958 cites W1991263027 @default.
• W2945355958 cites W2002065366 @default.
• W2945355958 cites W2008787569 @default.
• W2945355958 cites W2010179451 @default.
• W2945355958 cites W2016470388 @default.
• W2945355958 cites W2016619600 @default.
• W2945355958 cites W2017761002 @default.
• W2945355958 cites W2019256890 @default.
• W2945355958 cites W2020124596 @default.
• W2945355958 cites W2026948475 @default.
• W2945355958 cites W2032338900 @default.
• W2945355958 cites W2038683700 @default.
• W2945355958 cites W2045533786 @default.
• W2945355958 cites W2045988498 @default.
• W2945355958 cites W2048685634 @default.
• W2945355958 cites W2050938054 @default.
• W2945355958 cites W2056410559 @default.
• W2945355958 cites W2057495460 @default.
• W2945355958 cites W2057871713 @default.
• W2945355958 cites W2058638257 @default.
• W2945355958 cites W2062376915 @default.
• W2945355958 cites W2065298161 @default.
• W2945355958 cites W2073981718 @default.
• W2945355958 cites W2076153333 @default.
• W2945355958 cites W2087863751 @default.
• W2945355958 cites W2097049162 @default.
• W2945355958 cites W2098676436 @default.
• W2945355958 cites W2109270957 @default.
• W2945355958 cites W2112768538 @default.
• W2945355958 cites W2117099953 @default.
• W2945355958 cites W2126489565 @default.
• W2945355958 cites W2126525177 @default.
• W2945355958 cites W2128984013 @default.
• W2945355958 cites W2133569747 @default.
• W2945355958 cites W2139383170 @default.
• W2945355958 cites W2141260882 @default.
• W2945355958 cites W2155747798 @default.
• W2945355958 cites W2157239737 @default.
• W2945355958 cites W2163643313 @default.
• W2945355958 cites W2166931244 @default.
• W2945355958 cites W2167820441 @default.
• W2945355958 cites W2171530935 @default.
• W2945355958 cites W2277356999 @default.
• W2945355958 cites W2299603905 @default.
• W2945355958 cites W238453692 @default.
• W2945355958 cites W2502931751 @default.
• W2945355958 cites W2525908259 @default.
• W2945355958 cites W2549552700 @default.
• W2945355958 cites W2571630494 @default.
• W2945355958 cites W2589881680 @default.
• W2945355958 cites W2605465471 @default.
• W2945355958 cites W2757148163 @default.
• W2945355958 cites W2781296510 @default.
• W2945355958 cites W2800616945 @default.
• W2945355958 cites W2820472930 @default.
• W2945355958 cites W2899014762 @default.
• W2945355958 cites W2899796115 @default.
• W2945355958 cites W2901345444 @default.
• W2945355958 cites W2901527822 @default.
• W2945355958 cites W2903020671 @default.
• W2945355958 cites W2926631246 @default.
• W2945355958 cites W2950045154 @default.
• W2945355958 cites W2999063211 @default.
• W2945355958 doi "https://doi.org/10.1101/645879" @default.
• W2945355958 hasPublicationYear "2019" @default.
• W2945355958 type Work @default.
• W2945355958 sameAs 2945355958 @default.
• W2945355958 citedByCount "0" @default.
• W2945355958 crossrefType "posted-content" @default.
• W2945355958 hasAuthorship W2945355958A5009849937 @default.
• W2945355958 hasAuthorship W2945355958A5024277256 @default.
• W2945355958 hasAuthorship W2945355958A5029602658 @default.
• W2945355958 hasAuthorship W2945355958A5031213755 @default.

• next