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- W2945361303 abstract "Mood disorders are associated with omega-3 fatty acid deficits and structural and functional connectivity abnormalities within prefrontal cortex (PFC) networks. Reciprocal connections between the medial PFC (mPFC) and amygdala undergo robust synaptic pruning during adolescence in rats. Prior evidence suggests that the omega-3 fatty acids promote synaptogenesis and synaptic pruning. However, the role of omega-3 fatty acids in mPFC structural maturation and plasticity is not known. This study investigated whether developmental deficits in brain DHA accrual alter basal and amphetamine (AMPH)-induced increases in dendritic spine density in the adult rat mPFC." @default.
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- W2945361303 date "2019-05-01" @default.
- W2945361303 modified "2023-09-25" @default.
- W2945361303 title "T121. Effects of Developmental Omega-3 Fatty Acid Deficiency on Dendritic Spine Density and Plasticity in the Adult Rat Medial Prefrontal Cortex" @default.
- W2945361303 doi "https://doi.org/10.1016/j.biopsych.2019.03.444" @default.
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