Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945365847> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2945365847 endingPage "1012" @default.
- W2945365847 startingPage "1007" @default.
- W2945365847 abstract "We have investigated the mechanism and reactivity of covalent bond formation between cysteine-84 of the regulatory domain of cardiac troponin C and compounds containing a nitrile moiety similar to the calcium sensitizer levosimendan. The results of modifications to the levosimendan framework ranged from a large increase in covalent bond formation to complete inactivity. We present the biological activity of one of the most potent compounds. Limitations, including compound solubility and degradation at acidic pH, have prevented thorough investigation of the potential of these compounds. Our studies reveal the efficacious nature of the malononitrile moiety in targeting cNTnC and its potential in future cardiotonic drug design." @default.
- W2945365847 created "2019-05-29" @default.
- W2945365847 creator A5002381283 @default.
- W2945365847 creator A5043004749 @default.
- W2945365847 creator A5047925995 @default.
- W2945365847 creator A5064564309 @default.
- W2945365847 creator A5067477469 @default.
- W2945365847 creator A5089954562 @default.
- W2945365847 date "2019-05-15" @default.
- W2945365847 modified "2023-09-30" @default.
- W2945365847 title "Thioimidate Bond Formation between Cardiac Troponin C and Nitrile-containing Compounds" @default.
- W2945365847 cites W1901823973 @default.
- W2945365847 cites W1941606642 @default.
- W2945365847 cites W1986373711 @default.
- W2945365847 cites W1990049123 @default.
- W2945365847 cites W1993743949 @default.
- W2945365847 cites W1995797072 @default.
- W2945365847 cites W2004203772 @default.
- W2945365847 cites W2022558488 @default.
- W2945365847 cites W2029794453 @default.
- W2945365847 cites W2034375022 @default.
- W2945365847 cites W2037843599 @default.
- W2945365847 cites W2045809294 @default.
- W2945365847 cites W2057062150 @default.
- W2945365847 cites W2092099825 @default.
- W2945365847 cites W2102125543 @default.
- W2945365847 cites W2111124320 @default.
- W2945365847 cites W2117024383 @default.
- W2945365847 cites W2135490768 @default.
- W2945365847 cites W2153977062 @default.
- W2945365847 cites W2272683596 @default.
- W2945365847 cites W2334184216 @default.
- W2945365847 cites W2523885572 @default.
- W2945365847 cites W2548494392 @default.
- W2945365847 cites W2789407768 @default.
- W2945365847 doi "https://doi.org/10.1021/acsmedchemlett.9b00168" @default.
- W2945365847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7227049" @default.
- W2945365847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32426091" @default.
- W2945365847 hasPublicationYear "2019" @default.
- W2945365847 type Work @default.
- W2945365847 sameAs 2945365847 @default.
- W2945365847 citedByCount "4" @default.
- W2945365847 countsByYear W29453658472020 @default.
- W2945365847 countsByYear W29453658472021 @default.
- W2945365847 countsByYear W29453658472023 @default.
- W2945365847 crossrefType "journal-article" @default.
- W2945365847 hasAuthorship W2945365847A5002381283 @default.
- W2945365847 hasAuthorship W2945365847A5043004749 @default.
- W2945365847 hasAuthorship W2945365847A5047925995 @default.
- W2945365847 hasAuthorship W2945365847A5064564309 @default.
- W2945365847 hasAuthorship W2945365847A5067477469 @default.
- W2945365847 hasAuthorship W2945365847A5089954562 @default.
- W2945365847 hasBestOaLocation W29453658471 @default.
- W2945365847 hasConcept C10138342 @default.
- W2945365847 hasConcept C144133560 @default.
- W2945365847 hasConcept C178790620 @default.
- W2945365847 hasConcept C185592680 @default.
- W2945365847 hasConcept C2779240715 @default.
- W2945365847 hasConcept C69738904 @default.
- W2945365847 hasConceptScore W2945365847C10138342 @default.
- W2945365847 hasConceptScore W2945365847C144133560 @default.
- W2945365847 hasConceptScore W2945365847C178790620 @default.
- W2945365847 hasConceptScore W2945365847C185592680 @default.
- W2945365847 hasConceptScore W2945365847C2779240715 @default.
- W2945365847 hasConceptScore W2945365847C69738904 @default.
- W2945365847 hasFunder F4320307845 @default.
- W2945365847 hasFunder F4320310787 @default.
- W2945365847 hasFunder F4320319927 @default.
- W2945365847 hasFunder F4320319952 @default.
- W2945365847 hasFunder F4320320994 @default.
- W2945365847 hasFunder F4320334593 @default.
- W2945365847 hasIssue "6" @default.
- W2945365847 hasLocation W29453658471 @default.
- W2945365847 hasLocation W29453658472 @default.
- W2945365847 hasLocation W29453658473 @default.
- W2945365847 hasOpenAccess W2945365847 @default.
- W2945365847 hasPrimaryLocation W29453658471 @default.
- W2945365847 hasRelatedWork W2002527157 @default.
- W2945365847 hasRelatedWork W2012961986 @default.
- W2945365847 hasRelatedWork W2119696589 @default.
- W2945365847 hasRelatedWork W2402712172 @default.
- W2945365847 hasRelatedWork W2604173082 @default.
- W2945365847 hasRelatedWork W2605239016 @default.
- W2945365847 hasRelatedWork W2950412801 @default.
- W2945365847 hasRelatedWork W2952496829 @default.
- W2945365847 hasRelatedWork W2952704570 @default.
- W2945365847 hasRelatedWork W2988002722 @default.
- W2945365847 hasVolume "10" @default.
- W2945365847 isParatext "false" @default.
- W2945365847 isRetracted "false" @default.
- W2945365847 magId "2945365847" @default.
- W2945365847 workType "article" @default.