FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945370260> ?p ?o ?g. }

• W2945370260 endingPage "1630" @default.
• W2945370260 startingPage "1613" @default.
• W2945370260 abstract "Abstract Developmental exposures to phthalates are suspected to contribute to risk of metabolic syndrome. However, findings from human studies are inconsistent, and long-term metabolic impacts of early-life phthalate and phthalate mixture exposures are not fully understood. Furthermore, most animal studies investigating metabolic impacts of developmental phthalate exposures have focused on diethylhexyl phthalate (DEHP), whereas newer phthalates, such as diisononyl phthalate (DINP), are understudied. We used a longitudinal mouse model to evaluate long-term metabolic impacts of perinatal exposures to three individual phthalates, DEHP, DINP, and dibutyl phthalate (DBP), as well as two mixtures (DEHP+DINP and DEHP+DINP+DBP). Phthalates were administered to pregnant and lactating females through phytoestrogen-free chow at the following exposure levels: 25 mg of DEHP/kg of chow, 25 mg of DBP/kg of chow, and 75 mg of DINP/kg of chow. One male and female per litter (n = 9 to 13 per sex per group) were weaned onto control chow and followed until 10 months of age. They underwent metabolic phenotyping at 2 and 8 months, and adipokines were measured in plasma collected at 10 months. Longitudinally, females perinatally exposed to DEHP only had increased body fat percentage and decreased lean mass percentage, whereas females perinatally exposed to DINP only had impaired glucose tolerance. Perinatal phthalate exposures also modified the relationship between body fat percentage and plasma adipokine levels at 10 months in females. Phthalate-exposed males did not exhibit statistically significant differences in the measured longitudinal metabolic outcomes. Surprisingly, perinatal phthalate mixture exposures were statistically significantly associated with few metabolic effects and were not associated with larger effects than single exposures, revealing complexities in metabolic effects of developmental phthalate mixture exposures." @default.
• W2945370260 created "2019-05-29" @default.
• W2945370260 creator A5014292364 @default.
• W2945370260 creator A5034878023 @default.
• W2945370260 creator A5073554595 @default.
• W2945370260 creator A5075238484 @default.
• W2945370260 creator A5086484326 @default.
• W2945370260 creator A5087912540 @default.
• W2945370260 date "2019-05-24" @default.
• W2945370260 modified "2023-10-15" @default.
• W2945370260 title "Longitudinal Metabolic Impacts of Perinatal Exposure to Phthalates and Phthalate Mixtures in Mice" @default.
• W2945370260 cites W1172521185 @default.
• W2945370260 cites W1588758970 @default.
• W2945370260 cites W1964239883 @default.
• W2945370260 cites W1967667217 @default.
• W2945370260 cites W1976906208 @default.
• W2945370260 cites W1983290283 @default.
• W2945370260 cites W1989093319 @default.
• W2945370260 cites W1989517537 @default.
• W2945370260 cites W1990338377 @default.
• W2945370260 cites W1994988815 @default.
• W2945370260 cites W2008248550 @default.
• W2945370260 cites W2008370344 @default.
• W2945370260 cites W2015275965 @default.
• W2945370260 cites W2017707375 @default.
• W2945370260 cites W2023158177 @default.
• W2945370260 cites W2037336452 @default.
• W2945370260 cites W2046672109 @default.
• W2945370260 cites W2048655519 @default.
• W2945370260 cites W2056618157 @default.
• W2945370260 cites W2068576828 @default.
• W2945370260 cites W2072238442 @default.
• W2945370260 cites W2073295043 @default.
• W2945370260 cites W2076203191 @default.
• W2945370260 cites W2078538513 @default.
• W2945370260 cites W2084110570 @default.
• W2945370260 cites W2088260016 @default.
• W2945370260 cites W2097127734 @default.
• W2945370260 cites W2100489386 @default.
• W2945370260 cites W2105845983 @default.
• W2945370260 cites W2116806434 @default.
• W2945370260 cites W2117923938 @default.
• W2945370260 cites W2126437509 @default.
• W2945370260 cites W2143847855 @default.
• W2945370260 cites W2148249667 @default.
• W2945370260 cites W2156073806 @default.
• W2945370260 cites W2169101393 @default.
• W2945370260 cites W2205803035 @default.
• W2945370260 cites W2233186644 @default.
• W2945370260 cites W2290407493 @default.
• W2945370260 cites W2326111428 @default.
• W2945370260 cites W2482531029 @default.
• W2945370260 cites W2532088135 @default.
• W2945370260 cites W2535762306 @default.
• W2945370260 cites W2581337084 @default.
• W2945370260 cites W2593054240 @default.
• W2945370260 cites W2607316897 @default.
• W2945370260 cites W2763886030 @default.
• W2945370260 cites W2782595537 @default.
• W2945370260 cites W2884057346 @default.
• W2945370260 cites W2884658619 @default.
• W2945370260 cites W2917829637 @default.
• W2945370260 cites W892070084 @default.
• W2945370260 doi "https://doi.org/10.1210/en.2019-00287" @default.
• W2945370260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6589074" @default.
• W2945370260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31125050" @default.
• W2945370260 hasPublicationYear "2019" @default.
• W2945370260 type Work @default.
• W2945370260 sameAs 2945370260 @default.
• W2945370260 citedByCount "22" @default.
• W2945370260 countsByYear W29453702602020 @default.
• W2945370260 countsByYear W29453702602021 @default.
• W2945370260 countsByYear W29453702602022 @default.
• W2945370260 countsByYear W29453702602023 @default.
• W2945370260 crossrefType "journal-article" @default.
• W2945370260 hasAuthorship W2945370260A5014292364 @default.
• W2945370260 hasAuthorship W2945370260A5034878023 @default.
• W2945370260 hasAuthorship W2945370260A5073554595 @default.
• W2945370260 hasAuthorship W2945370260A5075238484 @default.
• W2945370260 hasAuthorship W2945370260A5086484326 @default.
• W2945370260 hasAuthorship W2945370260A5087912540 @default.
• W2945370260 hasBestOaLocation W29453702601 @default.
• W2945370260 hasConcept C112672928 @default.
• W2945370260 hasConcept C126322002 @default.
• W2945370260 hasConcept C134018914 @default.
• W2945370260 hasConcept C178790620 @default.
• W2945370260 hasConcept C185592680 @default.
• W2945370260 hasConcept C194832188 @default.
• W2945370260 hasConcept C2779234561 @default.
• W2945370260 hasConcept C2779429622 @default.
• W2945370260 hasConcept C2779643248 @default.
• W2945370260 hasConcept C2780613262 @default.
• W2945370260 hasConcept C2781005124 @default.
• W2945370260 hasConcept C511355011 @default.
• W2945370260 hasConcept C54355233 @default.
• W2945370260 hasConcept C6557445 @default.
• W2945370260 hasConcept C71924100 @default.
• W2945370260 hasConcept C86803240 @default.

• next