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- W2945385850 abstract "Abstract To accompany a theme issue on the treatment of three multidrugresistant (MDR) bacteria, the current editorial summarizes the poor state of the evidence on the optimal antibiotic treatment of carbapenemresistant. Gram-negative bacteria. We propose observational study designs addressing the main areas of bias in existing observational data:selection bias due to treatment by indication and standardization of the treatment groups. We propose novel randomized control trial (RCT) designs that will allow efficient and cost-effective recruitment of patients with carbapenem-resistant Gram-negative bacteria. Registry-based RCTs with adaptive designs could make use of existing MDR surveillance systems. Non-inferiority plus superiority hybrid designs may combine a. non-inferiority aim in the entire sample with a superiority design for the MDR subgroup. A paradigm shift is needed in clinical study design to create a solid evidence-base for the optimal treatment of MDR bacteria." @default.
- W2945385850 created "2019-05-29" @default.
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- W2945385850 date "2019-08-01" @default.
- W2945385850 modified "2023-10-12" @default.
- W2945385850 title "Clinical research designs to study treatment effects for multidrug-resistant bacteria" @default.
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- W2945385850 doi "https://doi.org/10.1016/j.cmi.2019.05.004" @default.
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