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• W2945390636 abstract "Long noncoding RNAs (lncRNAs) represent a group of regulatory RNAs that play critical roles in numerous cellular events, but their functional importance in development remains largely unexplored. Here, we discovered a series of previously unidentified gene clusters harboring conserved lncRNAs at the nonimprinting regions in brain (CNIBs). Among the seven identified CNIBs, human CNIB1 locus is located at Chr 9q33.3 and conserved from Danio rerio to Homo sapiens. Chr 9q33.3-9q34.11 microdeletion has previously been linked to human nail-patella syndrome (NPS) which is frequently accompanied by developmental and visual deficiencies. By generating CNIB1 deletion alleles in zebrafish, we demonstrated the requirement of CNIB1 for proper growth and development, and visual activities. Furthermore, we found that the role of CNIB1 on visual activity is mediated through a regulator of ocular development-lmx1bb. Collectively, our study shows that CNIB1 lncRNAs are important for zebrafish development and provides an lncRNA cluster-mediated pathophysiological mechanism for human Chr 9q33.3-9q34.11 microdeletion syndrome." @default.
• W2945390636 created "2019-05-29" @default.
• W2945390636 creator A5007090022 @default.
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• W2945390636 creator A5076787351 @default.
• W2945390636 creator A5086529957 @default.
• W2945390636 date "2019-05-25" @default.
• W2945390636 modified "2023-10-17" @default.
• W2945390636 title "A long noncoding RNA cluster-based genomic locus maintains proper development and visual function" @default.
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• W2945390636 doi "https://doi.org/10.1093/nar/gkz444" @default.
• W2945390636 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6614851" @default.
• W2945390636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31127312" @default.

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