Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945392909> ?p ?o ?g. }
- W2945392909 abstract "ABSTRACT In many organisms, early embryonic development is driven by maternally provided factors until the controlled onset of transcription during zygotic genome activation. The regulation of chromatin accessibility and its relationship to gene activity during this transition remains poorly understood. Here, we generated chromatin accessibility maps from genome activation until the onset of lineage specification. During this period, chromatin accessibility increases at regulatory elements. This increase is independent of RNA polymerase II-mediated transcription, with the exception of the hyper-transcribed miR-430 locus. Instead, accessibility often precedes the transcription of associated genes. Loss of the maternal transcription factors Pou5f3, Sox19b, and Nanog, which are known to be required for zebrafish genome activation, results in decreased accessibility at regulatory elements. Importantly, the accessibility of regulatory regions, especially when established by Pou5f3, Sox19b and Nanog, is predictive for future transcription. Our results show that the maternally provided transcription factors Pou5f3, Sox19b, and Nanog open up chromatin and prime genes for activity during zygotic genome activation in zebrafish." @default.
- W2945392909 created "2019-05-29" @default.
- W2945392909 creator A5029031227 @default.
- W2945392909 creator A5049205128 @default.
- W2945392909 creator A5061865787 @default.
- W2945392909 creator A5067360861 @default.
- W2945392909 date "2019-05-16" @default.
- W2945392909 modified "2023-09-27" @default.
- W2945392909 title "Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation" @default.
- W2945392909 cites W1531821806 @default.
- W2945392909 cites W1602754405 @default.
- W2945392909 cites W1818806520 @default.
- W2945392909 cites W1852765186 @default.
- W2945392909 cites W1961074127 @default.
- W2945392909 cites W1964951991 @default.
- W2945392909 cites W1964963969 @default.
- W2945392909 cites W1966683790 @default.
- W2945392909 cites W1968065062 @default.
- W2945392909 cites W1971451591 @default.
- W2945392909 cites W1978062497 @default.
- W2945392909 cites W1979513200 @default.
- W2945392909 cites W1981059575 @default.
- W2945392909 cites W1990620111 @default.
- W2945392909 cites W1993502678 @default.
- W2945392909 cites W2010275561 @default.
- W2945392909 cites W2011702976 @default.
- W2945392909 cites W2017224987 @default.
- W2945392909 cites W2038254017 @default.
- W2945392909 cites W2044911975 @default.
- W2945392909 cites W2048899247 @default.
- W2945392909 cites W2049368206 @default.
- W2945392909 cites W2051875167 @default.
- W2945392909 cites W2054717718 @default.
- W2945392909 cites W2060713924 @default.
- W2945392909 cites W2067651011 @default.
- W2945392909 cites W2068283269 @default.
- W2945392909 cites W2102136017 @default.
- W2945392909 cites W2107771229 @default.
- W2945392909 cites W2108445577 @default.
- W2945392909 cites W2108603029 @default.
- W2945392909 cites W2111562710 @default.
- W2945392909 cites W2117669477 @default.
- W2945392909 cites W2117757143 @default.
- W2945392909 cites W2118305000 @default.
- W2945392909 cites W2125349610 @default.
- W2945392909 cites W2128606977 @default.
- W2945392909 cites W2129078669 @default.
- W2945392909 cites W2140443734 @default.
- W2945392909 cites W2155718935 @default.
- W2945392909 cites W2157009395 @default.
- W2945392909 cites W2157205823 @default.
- W2945392909 cites W2171808845 @default.
- W2945392909 cites W2402498701 @default.
- W2945392909 cites W2409806253 @default.
- W2945392909 cites W2443585466 @default.
- W2945392909 cites W2465074434 @default.
- W2945392909 cites W2549864964 @default.
- W2945392909 cites W2565257179 @default.
- W2945392909 cites W2571829893 @default.
- W2945392909 cites W2594035655 @default.
- W2945392909 cites W2595380755 @default.
- W2945392909 cites W2605545409 @default.
- W2945392909 cites W2623740927 @default.
- W2945392909 cites W2724521833 @default.
- W2945392909 cites W2736547131 @default.
- W2945392909 cites W2766545389 @default.
- W2945392909 cites W2768417561 @default.
- W2945392909 cites W2769218776 @default.
- W2945392909 cites W2770368822 @default.
- W2945392909 cites W2782877284 @default.
- W2945392909 cites W2793965282 @default.
- W2945392909 cites W2799498847 @default.
- W2945392909 cites W2800912249 @default.
- W2945392909 cites W2802090556 @default.
- W2945392909 cites W2802302382 @default.
- W2945392909 cites W2803271184 @default.
- W2945392909 cites W2805068513 @default.
- W2945392909 cites W2808408669 @default.
- W2945392909 cites W2808421356 @default.
- W2945392909 cites W2884892406 @default.
- W2945392909 cites W2887694579 @default.
- W2945392909 cites W2900649558 @default.
- W2945392909 cites W2909484275 @default.
- W2945392909 cites W2911377753 @default.
- W2945392909 cites W2911555896 @default.
- W2945392909 cites W2935111625 @default.
- W2945392909 cites W2949236108 @default.
- W2945392909 cites W2953345807 @default.
- W2945392909 cites W3105775360 @default.
- W2945392909 doi "https://doi.org/10.1101/639302" @default.
- W2945392909 hasPublicationYear "2019" @default.
- W2945392909 type Work @default.
- W2945392909 sameAs 2945392909 @default.
- W2945392909 citedByCount "0" @default.
- W2945392909 crossrefType "posted-content" @default.
- W2945392909 hasAuthorship W2945392909A5029031227 @default.
- W2945392909 hasAuthorship W2945392909A5049205128 @default.
- W2945392909 hasAuthorship W2945392909A5061865787 @default.
- W2945392909 hasAuthorship W2945392909A5067360861 @default.
- W2945392909 hasBestOaLocation W29453929091 @default.