FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945405568> ?p ?o ?g. }

• W2945405568 endingPage "R202" @default.
• W2945405568 startingPage "R190" @default.
• W2945405568 abstract "Proinflammatory cytokines like interleukin-1β (IL-1β) affect the control of breathing. Our aim is to determine the effect of the anti-inflammatory cytokine IL-10 οn the control of breathing. IL-10 knockout mice (IL-10-/-, n = 10) and wild-type mice (IL-10+/+, n = 10) were exposed to the following test gases: hyperoxic hypercapnia 7% CO2-93% O2, normoxic hypercapnia 7% CO2-21% O2, hypoxic hypercapnia 7% CO2-10% O2, and hypoxic normocapnia 3% CO2-10% O2. The ventilatory function was assessed using whole body plethysmography. Recombinant mouse IL-10 (rIL-10; 10 μg/kg) was administered intraperitoneally to wild-type mice (n = 10) 30 min before the onset of gas challenge. IL-10 was administered in neonatal medullary slices (10-30 ng/ml, n = 8). We found that IL-10-/- mice exhibited consistently increased frequency and reduced tidal volume compared with IL-10+/+ mice during room air breathing and in all test gases (by 23.62 to 33.2%, P < 0.05 and -36.23 to -41.69%, P < 0.05, respectively). In all inspired gases, the minute ventilation of IL-10-/- mice was lower than IL-10+/+ (by -15.67 to -22.74%, P < 0.05). The rapid shallow breathing index was higher in IL-10-/- mice compared with IL-10+/+ mice in all inspired gases (by 50.25 to 57.5%, P < 0.05). The intraperitoneal injection of rIL-10 caused reduction of the respiratory rate and augmentation of the tidal volume in room air and also in all inspired gases (by -12.22 to -29.53 and 32.18 to 45.11%, P < 0.05, respectively). IL-10 administration in neonatal rat (n = 8) in vitro rhythmically active medullary slice preparations did not affect either rhythmicity or peak amplitude of hypoglossal nerve discharge. In conclusion, IL-10 may induce a slower and deeper pattern of breathing." @default.
• W2945405568 created "2019-05-29" @default.
• W2945405568 creator A5000317384 @default.
• W2945405568 creator A5004084316 @default.
• W2945405568 creator A5016435184 @default.
• W2945405568 creator A5022229801 @default.
• W2945405568 creator A5022718733 @default.
• W2945405568 creator A5045507434 @default.
• W2945405568 creator A5047051936 @default.
• W2945405568 creator A5055862510 @default.
• W2945405568 creator A5058020075 @default.
• W2945405568 creator A5060304210 @default.
• W2945405568 creator A5068927620 @default.
• W2945405568 creator A5074507276 @default.
• W2945405568 creator A5080439167 @default.
• W2945405568 creator A5085618693 @default.
• W2945405568 date "2019-07-01" @default.
• W2945405568 modified "2023-09-25" @default.
• W2945405568 title "Regulation of breathing pattern by IL-10" @default.
• W2945405568 cites W1209070443 @default.
• W2945405568 cites W1501159332 @default.
• W2945405568 cites W1516745984 @default.
• W2945405568 cites W1566992315 @default.
• W2945405568 cites W1571900525 @default.
• W2945405568 cites W1599289141 @default.
• W2945405568 cites W1721601994 @default.
• W2945405568 cites W1771861227 @default.
• W2945405568 cites W1847279168 @default.
• W2945405568 cites W1940376800 @default.
• W2945405568 cites W1964326122 @default.
• W2945405568 cites W1966176812 @default.
• W2945405568 cites W1969336325 @default.
• W2945405568 cites W1976762583 @default.
• W2945405568 cites W1976776656 @default.
• W2945405568 cites W1977512324 @default.
• W2945405568 cites W1979570000 @default.
• W2945405568 cites W1985163057 @default.
• W2945405568 cites W1989316467 @default.
• W2945405568 cites W1991842115 @default.
• W2945405568 cites W1993843698 @default.
• W2945405568 cites W1995682657 @default.
• W2945405568 cites W1996991112 @default.
• W2945405568 cites W1999883073 @default.
• W2945405568 cites W2000310637 @default.
• W2945405568 cites W2002068032 @default.
• W2945405568 cites W2008298949 @default.
• W2945405568 cites W2012375609 @default.
• W2945405568 cites W2012615827 @default.
• W2945405568 cites W2014244995 @default.
• W2945405568 cites W2018075167 @default.
• W2945405568 cites W2020175179 @default.
• W2945405568 cites W2023980409 @default.
• W2945405568 cites W2023983775 @default.
• W2945405568 cites W2026821172 @default.
• W2945405568 cites W2030053463 @default.
• W2945405568 cites W2032833833 @default.
• W2945405568 cites W2034895578 @default.
• W2945405568 cites W2036500213 @default.
• W2945405568 cites W2042195683 @default.
• W2945405568 cites W2042843395 @default.
• W2945405568 cites W2045617696 @default.
• W2945405568 cites W2048449925 @default.
• W2945405568 cites W2058416358 @default.
• W2945405568 cites W2063196031 @default.
• W2945405568 cites W2077441094 @default.
• W2945405568 cites W2078423602 @default.
• W2945405568 cites W2078701378 @default.
• W2945405568 cites W2083699390 @default.
• W2945405568 cites W2086584071 @default.
• W2945405568 cites W2089211646 @default.
• W2945405568 cites W2092703130 @default.
• W2945405568 cites W2097594692 @default.
• W2945405568 cites W2100425825 @default.
• W2945405568 cites W2102114151 @default.
• W2945405568 cites W2110368376 @default.
• W2945405568 cites W2116389090 @default.
• W2945405568 cites W2123006849 @default.
• W2945405568 cites W2123830992 @default.
• W2945405568 cites W2126422119 @default.
• W2945405568 cites W2128055065 @default.
• W2945405568 cites W2131250478 @default.
• W2945405568 cites W2137045670 @default.
• W2945405568 cites W2141777538 @default.
• W2945405568 cites W2143753039 @default.
• W2945405568 cites W2153231621 @default.
• W2945405568 cites W2155095068 @default.
• W2945405568 cites W2158859900 @default.
• W2945405568 cites W2161074777 @default.
• W2945405568 cites W2163929163 @default.
• W2945405568 cites W2163943128 @default.
• W2945405568 cites W2164180841 @default.
• W2945405568 cites W2166997718 @default.
• W2945405568 cites W2170465120 @default.
• W2945405568 cites W2187109072 @default.
• W2945405568 cites W2221316846 @default.
• W2945405568 cites W2234934158 @default.
• W2945405568 cites W2275655655 @default.
• W2945405568 cites W2300881047 @default.

• next