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- W2945406204 abstract "To get more insight in platelet function of patients suffering from insufficiency of the circulation together with intravascular fibrin formation as a sign of a stimulated coagulation system, the following parameters were determined: 1. the prostaglandin-endoperoxide formation of platelets in response to N-ethylmaleimide and collagen measured as malondialdehyde; 2. the c-AMP content of platelets and plasma according to the Gilman method; 3. the stimulating effect of prostaglandin E1 on the platelets adenylate-cyclase activity; 4. the collagen induced platelet aggregation. Platelet aggregation was reduced. The prostaglandin-endoperoxide formation was unchanged or elevatedin comparison to normal donors. Plasma c-AMP was increased, whereas the platelet c-AMP content was unaltered. Adenylate cyclase activity in response to prostaglandin E1 was reduced. Platelet function recovered concomitantly with the improvement of the circulation and the clotting parameters." @default.
- W2945406204 created "2019-05-29" @default.
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- W2945406204 date "1977-01-01" @default.
- W2945406204 modified "2023-09-27" @default.
- W2945406204 title "Prostaglandin-Endoperoxides and Cyclic 3′-5′-AMP in Platelets of Patients with Hypercoagulability and Shock" @default.
- W2945406204 doi "https://doi.org/10.1055/s-0039-1680786" @default.
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