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- W2945408300 endingPage "657" @default.
- W2945408300 startingPage "657" @default.
- W2945408300 abstract "Serum pepsinogen assay (sPGA), which reveals serum pepsinogen (PG) I concentration and the PG I/PG II ratio, is a non-invasive test for predicting chronic atrophic gastritis (CAG) and gastric neoplasms. Although various cut-off values have been suggested, PG I ≤70 ng/mL and a PG I/PG II ratio of ≤3 have been proposed. However, previous meta-analyses reported insufficient systematic reviews and only pooled outcomes, which cannot determine the diagnostic validity of sPGA with a cut-off value of PG I ≤70 ng/mL and/or PG I/PG II ratio ≤3. We searched the core databases (MEDLINE, Cochrane Library, and Embase) from their inception to April 2018. Fourteen and 43 studies were identified and analyzed for the diagnostic performance in CAG and gastric neoplasms, respectively. Values for sensitivity, specificity, diagnostic odds ratio, and area under the curve with a cut-off value of PG I ≤70 ng/mL and PG I/PG II ratio ≤3 to diagnose CAG were 0.59, 0.89, 12, and 0.81, respectively and for diagnosis of gastric cancer (GC) these values were 0.59, 0.73, 4, and 0.7, respectively. Methodological quality and ethnicity of enrolled studies were found to be the reason for the heterogeneity in CAG diagnosis. Considering the high specificity, non-invasiveness, and easily interpretable characteristics, sPGA has potential for screening of CAG or GC." @default.
- W2945408300 created "2019-05-29" @default.
- W2945408300 creator A5019618986 @default.
- W2945408300 creator A5044014459 @default.
- W2945408300 creator A5045012652 @default.
- W2945408300 date "2019-05-10" @default.
- W2945408300 modified "2023-10-01" @default.
- W2945408300 title "Prediction of Chronic Atrophic Gastritis and Gastric Neoplasms by Serum Pepsinogen Assay: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy" @default.
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- W2945408300 doi "https://doi.org/10.3390/jcm8050657" @default.
- W2945408300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6572271" @default.
- W2945408300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31083485" @default.
- W2945408300 hasPublicationYear "2019" @default.
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