FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945409063> ?p ?o ?g. }

• W2945409063 endingPage "1951" @default.
• W2945409063 startingPage "1951" @default.
• W2945409063 abstract "The human KRAS (Kirsten rat sarcoma) is an oncogene, involved in the regulation of cell growth and division. The mutations in the KRAS gene have the potential to cause normal cells to become cancerous in human lungs. In the present study, we focus on non-synonymous single nucleotide polymorphisms (nsSNPs), which are point mutations in the DNA sequence leading to the amino acid variants in the encoded protein. To begin with, we developed a pipeline to utilize a set of computational tools in order to obtain the most deleterious nsSNPs (Q22K, Q61P, and Q61R) associated with lung cancer in the human KRAS gene. Furthermore, molecular dynamics simulation and structural analyses of the 3D structures of native and mutant proteins confirmed the impact of these nsSNPs on the stability of the protein. Finally, the experimental results demonstrated that the structural stability of the mutant proteins was worse than that of the native protein. This study provides significant guidance for narrowing down the number of KRAS mutations to be screened as potential diagnostic biomarkers and to better understand the structural and functional mechanisms of the KRAS protein." @default.
• W2945409063 created "2019-05-29" @default.
• W2945409063 creator A5014672057 @default.
• W2945409063 creator A5048249770 @default.
• W2945409063 creator A5062315365 @default.
• W2945409063 creator A5081555190 @default.
• W2945409063 creator A5085331622 @default.
• W2945409063 creator A5089620745 @default.
• W2945409063 date "2019-05-21" @default.
• W2945409063 modified "2023-10-05" @default.
• W2945409063 title "Computational Screening and Analysis of Lung Cancer Related Non-Synonymous Single Nucleotide Polymorphisms on the Human Kirsten Rat Sarcoma Gene" @default.
• W2945409063 cites W1031578623 @default.
• W2945409063 cites W1607931568 @default.
• W2945409063 cites W1683278196 @default.
• W2945409063 cites W1966078827 @default.
• W2945409063 cites W1980740976 @default.
• W2945409063 cites W1991340932 @default.
• W2945409063 cites W1992073257 @default.
• W2945409063 cites W2013028402 @default.
• W2945409063 cites W2024405748 @default.
• W2945409063 cites W2031570350 @default.
• W2945409063 cites W2057477511 @default.
• W2945409063 cites W2092044893 @default.
• W2945409063 cites W2099589970 @default.
• W2945409063 cites W2109154308 @default.
• W2945409063 cites W2114784462 @default.
• W2945409063 cites W2114886480 @default.
• W2945409063 cites W2121519777 @default.
• W2945409063 cites W2122732537 @default.
• W2945409063 cites W2130479394 @default.
• W2945409063 cites W2134640949 @default.
• W2945409063 cites W2136513422 @default.
• W2945409063 cites W2137297899 @default.
• W2945409063 cites W2137886330 @default.
• W2945409063 cites W2141965353 @default.
• W2945409063 cites W2150444353 @default.
• W2945409063 cites W2171268876 @default.
• W2945409063 cites W2195303995 @default.
• W2945409063 cites W2376573086 @default.
• W2945409063 cites W2428593791 @default.
• W2945409063 cites W2555043131 @default.
• W2945409063 cites W2603411876 @default.
• W2945409063 cites W2765681696 @default.
• W2945409063 cites W2769412055 @default.
• W2945409063 cites W2801491392 @default.
• W2945409063 cites W2883160489 @default.
• W2945409063 cites W2890211250 @default.
• W2945409063 cites W415465015 @default.
• W2945409063 cites W4211196614 @default.
• W2945409063 doi "https://doi.org/10.3390/molecules24101951" @default.
• W2945409063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6572712" @default.
• W2945409063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31117243" @default.
• W2945409063 hasPublicationYear "2019" @default.
• W2945409063 type Work @default.
• W2945409063 sameAs 2945409063 @default.
• W2945409063 citedByCount "27" @default.
• W2945409063 countsByYear W29454090632019 @default.
• W2945409063 countsByYear W29454090632020 @default.
• W2945409063 countsByYear W29454090632021 @default.
• W2945409063 countsByYear W29454090632022 @default.
• W2945409063 countsByYear W29454090632023 @default.
• W2945409063 crossrefType "journal-article" @default.
• W2945409063 hasAuthorship W2945409063A5014672057 @default.
• W2945409063 hasAuthorship W2945409063A5048249770 @default.
• W2945409063 hasAuthorship W2945409063A5062315365 @default.
• W2945409063 hasAuthorship W2945409063A5081555190 @default.
• W2945409063 hasAuthorship W2945409063A5085331622 @default.
• W2945409063 hasAuthorship W2945409063A5089620745 @default.
• W2945409063 hasBestOaLocation W29454090631 @default.
• W2945409063 hasConcept C104317684 @default.
• W2945409063 hasConcept C121608353 @default.
• W2945409063 hasConcept C135763542 @default.
• W2945409063 hasConcept C143065580 @default.
• W2945409063 hasConcept C153209595 @default.
• W2945409063 hasConcept C176944494 @default.
• W2945409063 hasConcept C2781187634 @default.
• W2945409063 hasConcept C2910786375 @default.
• W2945409063 hasConcept C501734568 @default.
• W2945409063 hasConcept C502942594 @default.
• W2945409063 hasConcept C54355233 @default.
• W2945409063 hasConcept C70721500 @default.
• W2945409063 hasConcept C86803240 @default.
• W2945409063 hasConceptScore W2945409063C104317684 @default.
• W2945409063 hasConceptScore W2945409063C121608353 @default.
• W2945409063 hasConceptScore W2945409063C135763542 @default.
• W2945409063 hasConceptScore W2945409063C143065580 @default.
• W2945409063 hasConceptScore W2945409063C153209595 @default.
• W2945409063 hasConceptScore W2945409063C176944494 @default.
• W2945409063 hasConceptScore W2945409063C2781187634 @default.
• W2945409063 hasConceptScore W2945409063C2910786375 @default.
• W2945409063 hasConceptScore W2945409063C501734568 @default.
• W2945409063 hasConceptScore W2945409063C502942594 @default.
• W2945409063 hasConceptScore W2945409063C54355233 @default.
• W2945409063 hasConceptScore W2945409063C70721500 @default.
• W2945409063 hasConceptScore W2945409063C86803240 @default.
• W2945409063 hasFunder F4320335305 @default.
• W2945409063 hasFunder F4320335595 @default.
• W2945409063 hasFunder F4320335777 @default.

• next