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• W2945429489 abstract "The study was conducted in the animal house of the faculty of veterinary medicine / university of al- Qadisiyah in order to identify the role of the alcoholic extract of sweet potato roots Ipomoea batatas portrico in the treatment of aspirin induced gastric ulcer by using 70 male rats of Rattus norvegicus. The animals was divided into two main groups as follows: the negative control group (C) was given the standard diet and distilled water only and the treatment groups (T), which developed peptic ulcer through oral dosage of (100 mg / kg body weight aspirin) for one week and then sacrificed 5 animals to confirm the presence of gastric ulcer and conducting the gross examination of the test. The treatment groups were divided into three groups, the first treatment group was considered as a positive control group (T1) or aspirin group only. The second group (T2) treated with (800 mg / kg body weight) extract of the sweet potato root by oral dose once daily for three consecutive weeks. The third treatment group (T3) was treated omeprazole orally (20 mg/kg bw) once daily for three consecutive weeks. The stomach was removed from each animal for the purpose of examining histological changes using three different stains: haematoxylin and eosin, Masson´s trichrome and periodic acid-schiff stain (PAS). The immunohistochemical teqnique was used to identify the epidermal growth factor receptors. The results of the histological examination using hematoxylin and eosin showed histopathological changes in the treatment group with aspirin in the gastric tissue represents by ulceration, congestion and infiltration of the inflammatory cells, bleeding, and thickening of the muscularis mucosae was observed in gastric tissue, While the disappearance of ulcers, bleeding and signs of congestion and gradual healing by the progressing of the experiment in animals treated with the extract of sweet potatoes(T2). The results showed by using (Masson and PAS) stains that there was a small or no amount of mucus and collagen fibers in the treatment group with aspirin (T1). However, there was a gradual increase in the amount of mucus and collagen fibers in the stomach tissue in the second and third treatment groups (T2, T3). The results of immunohistochemistry in the stomach showed no immune reaction to epidermal growth factor receptors in the (T1) treated animals group. The immunhistochemical staining was either very poor or absent, while a gradual increase in immune reaction and pigment strength was observed in the two groups of sweet potato extract (T2) and omeprazole (T1) groups with the duration of treatment.it was more pronounced in the animals of the second group (T2). The study concluded that the use of sweet potato root extract in the treatment of gastric ulcer had clear positive effects and was closed to omeprazole treatment." @default.
• W2945429489 created "2019-05-29" @default.
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• W2945429489 date "2019-05-10" @default.
• W2945429489 modified "2023-09-28" @default.
• W2945429489 title "Histological and immunohistochemical study of the healing role of the extract of Ipomoea batatas sweet potato extract in the gastric ulcer developed by aspirin in male albino rats" @default.
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