Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945442960> ?p ?o ?g. }
- W2945442960 endingPage "143" @default.
- W2945442960 startingPage "134" @default.
- W2945442960 abstract "In non-alcoholic fatty liver disease (NAFLD), an increased portal pressure is observed before signs of cirrhosis or even inflammation or fibrosis are histologically present. This review describes the differences between the mechanisms of cirrhotic portal hypertension (PHT) and PHT in non-cirrhotic NAFLD. The increased portal pressure in NAFLD is primarily a result of an increased intrahepatic vascular resistance. Vasodilation is decreased by endothelial dysfunction and the sensitivity to vasoconstrictors is increased. Furthermore, the activation of hepatic stellate cells and the presence of microvascular thrombosis could also be involved in the pathogenesis of PHT in NAFLD. Although the increased portal pressure in early NAFLD is not considered clinically significant PHT, it might play a role in the pathophysiology of NAFLD. Due to the increased intrahepatic vascular resistance, the hepatic blood flow is impaired and hence the oxygen delivery is decreased, potentially triggering transition to steatohepatitis. The underlying mechanisms of these alterations therefore represent promising targets for pharmacological treatment." @default.
- W2945442960 created "2019-05-29" @default.
- W2945442960 creator A5023141788 @default.
- W2945442960 creator A5068672933 @default.
- W2945442960 creator A5070970519 @default.
- W2945442960 date "2019-05-14" @default.
- W2945442960 modified "2023-10-16" @default.
- W2945442960 title "Portal Hypertension in NASH: Is It Different from Other Aetiologies?" @default.
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