Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945443882> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2945443882 abstract "Cell membranes fulfil many important biological functions and are composed by an heterogeneous variety of lipids and proteins, which leads to the typical asymmetric bilayer structure. One of the main functions of cell membrane is to act as a filter to control the molecules traffic at the interface. The comprehension of the molecular transport across the membrane is hugely important in medicine, in particular in the development of effective drug delivery system. There are different routes for cellular uptake, some involving complex signalling pathways, some more simple. The easier way is the direct translocation through water pores. Indirect experimental evidences suggest the presence of small, short-lived pores for which todays experimental tools are unable to provide direct observation and atomistic detail. Here, through molecular modelling, the formation of these hydrophilic pores was observed and analysed. In particular, the focus was on the effect of the transmembrane potential, which has a strong influence on the transport of various small and large molecules across the membrane and leads to pore formation. In the present work, lipid pores were induced both applying an external, constant electric field and creating a physiologic-like charge imbalance across the membrane. Moreover, following the second approach, cellular uptake of seven different cell penetrating peptides (CPP) through direct translocation pathway driven by the membrane electrostatic potential was observed and studied. The opening of membrane pores due to the ion imbalance revealed to be broadly relevant for CPP uptake." @default.
- W2945443882 created "2019-05-29" @default.
- W2945443882 creator A5069114882 @default.
- W2945443882 date "2019-04-04" @default.
- W2945443882 modified "2023-09-27" @default.
- W2945443882 title "Membrane Electroporation Study by All-atom and Coarsed-grained Molecular Dynamics: from Pore Formation to Cell Penetrating Peptides Translocation" @default.
- W2945443882 hasPublicationYear "2019" @default.
- W2945443882 type Work @default.
- W2945443882 sameAs 2945443882 @default.
- W2945443882 citedByCount "0" @default.
- W2945443882 crossrefType "journal-article" @default.
- W2945443882 hasAuthorship W2945443882A5069114882 @default.
- W2945443882 hasConcept C104317684 @default.
- W2945443882 hasConcept C12554922 @default.
- W2945443882 hasConcept C147597530 @default.
- W2945443882 hasConcept C159467904 @default.
- W2945443882 hasConcept C170493617 @default.
- W2945443882 hasConcept C171250308 @default.
- W2945443882 hasConcept C178790620 @default.
- W2945443882 hasConcept C185592680 @default.
- W2945443882 hasConcept C186852380 @default.
- W2945443882 hasConcept C192157962 @default.
- W2945443882 hasConcept C192562407 @default.
- W2945443882 hasConcept C24530287 @default.
- W2945443882 hasConcept C2778106830 @default.
- W2945443882 hasConcept C32909587 @default.
- W2945443882 hasConcept C39944091 @default.
- W2945443882 hasConcept C41625074 @default.
- W2945443882 hasConcept C55493867 @default.
- W2945443882 hasConcept C57947595 @default.
- W2945443882 hasConcept C59593255 @default.
- W2945443882 hasConcept C86803240 @default.
- W2945443882 hasConceptScore W2945443882C104317684 @default.
- W2945443882 hasConceptScore W2945443882C12554922 @default.
- W2945443882 hasConceptScore W2945443882C147597530 @default.
- W2945443882 hasConceptScore W2945443882C159467904 @default.
- W2945443882 hasConceptScore W2945443882C170493617 @default.
- W2945443882 hasConceptScore W2945443882C171250308 @default.
- W2945443882 hasConceptScore W2945443882C178790620 @default.
- W2945443882 hasConceptScore W2945443882C185592680 @default.
- W2945443882 hasConceptScore W2945443882C186852380 @default.
- W2945443882 hasConceptScore W2945443882C192157962 @default.
- W2945443882 hasConceptScore W2945443882C192562407 @default.
- W2945443882 hasConceptScore W2945443882C24530287 @default.
- W2945443882 hasConceptScore W2945443882C2778106830 @default.
- W2945443882 hasConceptScore W2945443882C32909587 @default.
- W2945443882 hasConceptScore W2945443882C39944091 @default.
- W2945443882 hasConceptScore W2945443882C41625074 @default.
- W2945443882 hasConceptScore W2945443882C55493867 @default.
- W2945443882 hasConceptScore W2945443882C57947595 @default.
- W2945443882 hasConceptScore W2945443882C59593255 @default.
- W2945443882 hasConceptScore W2945443882C86803240 @default.
- W2945443882 hasLocation W29454438821 @default.
- W2945443882 hasOpenAccess W2945443882 @default.
- W2945443882 hasPrimaryLocation W29454438821 @default.
- W2945443882 hasRelatedWork W1587404680 @default.
- W2945443882 hasRelatedWork W174049033 @default.
- W2945443882 hasRelatedWork W1784419243 @default.
- W2945443882 hasRelatedWork W2003818636 @default.
- W2945443882 hasRelatedWork W2019317580 @default.
- W2945443882 hasRelatedWork W2050414897 @default.
- W2945443882 hasRelatedWork W2064287736 @default.
- W2945443882 hasRelatedWork W2064443354 @default.
- W2945443882 hasRelatedWork W2152041872 @default.
- W2945443882 hasRelatedWork W2159877851 @default.
- W2945443882 hasRelatedWork W2199868862 @default.
- W2945443882 hasRelatedWork W2217503625 @default.
- W2945443882 hasRelatedWork W2638251159 @default.
- W2945443882 hasRelatedWork W2796335833 @default.
- W2945443882 hasRelatedWork W2901755540 @default.
- W2945443882 hasRelatedWork W2909184263 @default.
- W2945443882 hasRelatedWork W2911021118 @default.
- W2945443882 hasRelatedWork W3033977315 @default.
- W2945443882 hasRelatedWork W3180113013 @default.
- W2945443882 hasRelatedWork W8143855 @default.
- W2945443882 isParatext "false" @default.
- W2945443882 isRetracted "false" @default.
- W2945443882 magId "2945443882" @default.
- W2945443882 workType "article" @default.